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CD1A

GENERAL INFORMATION

Gene name

 CD1A

Gene description

 CD1a molecule

Protein class

 CD markers
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (esophagus, skin)
GTEx:Tissue enhanced (skin)
FANTOM5:Tissue enhanced (lung, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in Langerhans cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA010734 , CAB000009
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung, tonsil)

GENE INFORMATION

Gene name

 CD1A (HGNC Symbol)

Synonyms

 CD1

Description

 CD1a molecule (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q23.1

Chromosome location (bp)

 158254137 - 158258269

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158477 (version 83.38)

Entrez gene

 909

UniProt

 P06126 (UniProt - Evidence at protein level)

neXtProt

 NX_P06126

Antibodypedia

 CD1A antibodies

PROTEIN BROWSER
CD1A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD1A-001
ENSP00000289429
ENST00000289429
P06126 [Direct mapping]
T-cell surface glycoprotein CD1a
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
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GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0010008 [endosome membrane]
GO:0030881 [beta-2-microglobulin binding]
GO:0030883 [endogenous lipid antigen binding]
GO:0030884 [exogenous lipid antigen binding]
GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib]
GO:0071723 [lipopeptide binding]
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 327 aa
37.1 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.