Expression of SPATA2 in cancer - Summary - The Human Protein Atlas

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SPATA2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SPATA2
Gene description	Spermatogenesis associated 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA048581
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), thyroid cancer (unfavourable) and melanoma (favourable).
Endometrial cancer p<0.001 Thyroid cancer p<0.001 Melanoma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048581

GENE INFORMATION
Gene name	SPATA2 (HGNC Symbol)
Synonyms	KIAA0757, PD1, PPP1R145, tamo
Description	Spermatogenesis associated 2 (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q13.13
Chromosome location (bp)	49903391 - 49915508
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158480 (version 83.38)
Entrez gene	9825
UniProt	Q9UM82 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UM82
Antibodypedia	SPATA2 antibodies

PROTEIN BROWSER

SPATA2-001	SPATA2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPATA2-001 ENSP00000289431 ENST00000289431	Q9UM82 [Direct mapping] Spermatogenesis-associated protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] Show all	520 aa 58.4 kDa	No	0
SPATA2-201 ENSP00000416799 ENST00000422556	Q9UM82 [Direct mapping] Spermatogenesis-associated protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] Show all	520 aa 58.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.