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CD1C

GENERAL INFORMATION

Gene name

 CD1C

Gene description

 CD1c molecule

Protein class

 CD markers
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (MOLT-4)
HPA (normal tissue):Tissue enhanced (spleen, tonsil)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CD1C (HGNC Symbol)

Synonyms

 CD1

Description

 CD1c molecule (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q23.1

Chromosome location (bp)

 158289786 - 158293630

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158481 (version 83.38)

Entrez gene

 911

UniProt

 P29017 (UniProt - Evidence at protein level)

neXtProt

 NX_P29017

Antibodypedia

 CD1C antibodies

PROTEIN BROWSER
CD1C-001
CD1C-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD1C-001
ENSP00000357152
ENST00000368170
P29017 [Direct mapping]
T-cell surface glycoprotein CD1c
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002250 [adaptive immune response]
GO:0002286 [T cell activation involved in immune response]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0010008 [endosome membrane]
GO:0030881 [beta-2-microglobulin binding]
GO:0030883 [endogenous lipid antigen binding]
GO:0030884 [exogenous lipid antigen binding]
GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib]
GO:0051861 [glycolipid binding]
GO:0071723 [lipopeptide binding]
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 333 aa
37.7 kDa 		Yes 1
CD1C-003
ENSP00000408755
ENST00000443761
H0Y6Y6 [Direct mapping]
T-cell surface glycoprotein CD1c
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0006955 [immune response]
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 281 aa
31.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.