Expression of CD1E in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CD1E
Gene description	CD1e molecule
Protein class	CD markers Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (MOLT-4)
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several different cell types, including immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA057769
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA057769

GENE INFORMATION
Gene name	CD1E
Synonyms
Description	CD1e molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]
Chromosome	1
Cytoband	q23.1
Chromosome location (bp)	158353696 - 158357553
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158488 (version 83.38)
Entrez gene	913
UniProt	P15812 (UniProt - Evidence at protein level)
neXtProt	NX_P15812
Antibodypedia	CD1E antibodies

PROTEIN BROWSER

CD1E-001	CD1E-002	CD1E-003	CD1E-004	CD1E-005	CD1E-006	CD1E-007	CD1E-008	CD1E-009	CD1E-010	CD1E-011	CD1E-012	CD1E-013	CD1E-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD1E-001 ENSP00000357149 ENST00000368167	P15812 [Direct mapping] T-cell surface glycoprotein CD1e, membrane-associated T-cell surface glycoprotein CD1e, soluble Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0030881 [beta-2-microglobulin binding] GO:0030883 [endogenous lipid antigen binding] GO:0030884 [exogenous lipid antigen binding] GO:0043202 [lysosomal lumen] GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib] GO:0071723 [lipopeptide binding] Show all	388 aa 43.6 kDa	Yes	1
CD1E-002 ENSP00000357139 ENST00000368157	P15812 [Direct mapping] T-cell surface glycoprotein CD1e, membrane-associated T-cell surface glycoprotein CD1e, soluble Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0030881 [beta-2-microglobulin binding] GO:0030883 [endogenous lipid antigen binding] GO:0030884 [exogenous lipid antigen binding] GO:0043202 [lysosomal lumen] GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib] GO:0071723 [lipopeptide binding] Show all	132 aa 15 kDa	Yes	1
CD1E-003 ENSP00000416228 ENST00000452291	P15812 [Direct mapping] T-cell surface glycoprotein CD1e, membrane-associated T-cell surface glycoprotein CD1e, soluble Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0030881 [beta-2-microglobulin binding] GO:0030883 [endogenous lipid antigen binding] GO:0030884 [exogenous lipid antigen binding] GO:0043202 [lysosomal lumen] GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib] GO:0071723 [lipopeptide binding] Show all	199 aa 22.3 kDa	Yes	1
CD1E-004 ENSP00000357148 ENST00000368166	P15812 [Direct mapping] T-cell surface glycoprotein CD1e, membrane-associated T-cell surface glycoprotein CD1e, soluble Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0030881 [beta-2-microglobulin binding] GO:0030883 [endogenous lipid antigen binding] GO:0030884 [exogenous lipid antigen binding] GO:0043202 [lysosomal lumen] GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib] GO:0071723 [lipopeptide binding] Show all	187 aa 21 kDa	Yes	1
CD1E-005 ENSP00000357142 ENST00000368160	P15812 [Direct mapping] T-cell surface glycoprotein CD1e, membrane-associated T-cell surface glycoprotein CD1e, soluble Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0030881 [beta-2-microglobulin binding] GO:0030883 [endogenous lipid antigen binding] GO:0030884 [exogenous lipid antigen binding] GO:0043202 [lysosomal lumen] GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib] GO:0071723 [lipopeptide binding] Show all	376 aa 42.3 kDa	Yes	1
CD1E-006 ENSP00000357143 ENST00000368161	P15812 [Direct mapping] T-cell surface glycoprotein CD1e, membrane-associated T-cell surface glycoprotein CD1e, soluble Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0030881 [beta-2-microglobulin binding] GO:0030883 [endogenous lipid antigen binding] GO:0030884 [exogenous lipid antigen binding] GO:0043202 [lysosomal lumen] GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib] GO:0071723 [lipopeptide binding] Show all	290 aa 32.7 kDa	Yes	0
CD1E-007 ENSP00000357145 ENST00000368163	P15812 [Direct mapping] T-cell surface glycoprotein CD1e, membrane-associated T-cell surface glycoprotein CD1e, soluble Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0030881 [beta-2-microglobulin binding] GO:0030883 [endogenous lipid antigen binding] GO:0030884 [exogenous lipid antigen binding] GO:0043202 [lysosomal lumen] GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib] GO:0071723 [lipopeptide binding] Show all	321 aa 36.4 kDa	Yes	1
CD1E-008 ENSP00000357147 ENST00000368165	P15812 [Direct mapping] T-cell surface glycoprotein CD1e, membrane-associated T-cell surface glycoprotein CD1e, soluble Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0030881 [beta-2-microglobulin binding] GO:0030883 [endogenous lipid antigen binding] GO:0030884 [exogenous lipid antigen binding] GO:0043202 [lysosomal lumen] GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib] GO:0071723 [lipopeptide binding] Show all	298 aa 33.6 kDa	Yes	1
CD1E-009 ENSP00000357138 ENST00000368156	P15812 [Direct mapping] T-cell surface glycoprotein CD1e, membrane-associated T-cell surface glycoprotein CD1e, soluble Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0030881 [beta-2-microglobulin binding] GO:0030883 [endogenous lipid antigen binding] GO:0030884 [exogenous lipid antigen binding] GO:0043202 [lysosomal lumen] GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib] GO:0071723 [lipopeptide binding] Show all	286 aa 32.3 kDa	Yes	1
CD1E-010 ENSP00000357137 ENST00000368155	P15812 [Direct mapping] T-cell surface glycoprotein CD1e, membrane-associated T-cell surface glycoprotein CD1e, soluble Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002250 [adaptive immune response] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0030881 [beta-2-microglobulin binding] GO:0030883 [endogenous lipid antigen binding] GO:0030884 [exogenous lipid antigen binding] GO:0043202 [lysosomal lumen] GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib] GO:0071723 [lipopeptide binding] Show all	231 aa 26.3 kDa	Yes	1
CD1E-011 ENSP00000357146 ENST00000368164	P15812 [Direct mapping] T-cell surface glycoprotein CD1e, membrane-associated T-cell surface glycoprotein CD1e, soluble Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0030881 [beta-2-microglobulin binding] GO:0030883 [endogenous lipid antigen binding] GO:0030884 [exogenous lipid antigen binding] GO:0043202 [lysosomal lumen] GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib] GO:0071723 [lipopeptide binding] Show all	101 aa 11.4 kDa	Yes	0
CD1E-012 ENSP00000357136 ENST00000368154	P15812 [Direct mapping] T-cell surface glycoprotein CD1e, membrane-associated T-cell surface glycoprotein CD1e, soluble Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0030881 [beta-2-microglobulin binding] GO:0030883 [endogenous lipid antigen binding] GO:0030884 [exogenous lipid antigen binding] GO:0043202 [lysosomal lumen] GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib] GO:0071723 [lipopeptide binding] Show all	144 aa 16.3 kDa	Yes	1
CD1E-013 ENSP00000357144 ENST00000368162	H0Y345 [Direct mapping] T-cell surface glycoprotein CD1e, membrane-associated Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	60 aa 6.9 kDa	No	0
CD1E-201 ENSP00000402906 ENST00000444681	P15812 [Direct mapping] T-cell surface glycoprotein CD1e, membrane-associated T-cell surface glycoprotein CD1e, soluble Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0030881 [beta-2-microglobulin binding] GO:0030883 [endogenous lipid antigen binding] GO:0030884 [exogenous lipid antigen binding] GO:0043202 [lysosomal lumen] GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib] GO:0071723 [lipopeptide binding] Show all	289 aa 32.3 kDa	Yes	1