Expression of CPA2 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CPA2
Gene description	Carboxypeptidase A2 (pancreatic)
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (pancreatic cancer)
HPA (cell line):	Cell line enhanced (AN3-CA, CACO-2, RH-30, SCLC-21H)
HPA (normal tissue):	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in exocrine pancreas and occasional pancreatic cancers.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 2 antibodies. HPA020342 , HPA021317
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA020342	HPA021317

GENE INFORMATION
Gene name	CPA2
Synonyms
Description	Carboxypeptidase A2 (pancreatic) (HGNC Symbol)
Entrez gene summary	Three different forms of human pancreatic procarboxypeptidase A have been isolated. The encoded protein represents the A2 form, which is a monomeric protein with different biochemical properties from the A1 and A3 forms. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues and is a secreted protein. [provided by RefSeq, Dec 2008]
Chromosome	7
Cytoband	q32.2
Chromosome location (bp)	130266827 - 130289798
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158516 (version 83.38)
Entrez gene	1358
UniProt	P48052 (UniProt - Evidence at protein level)
neXtProt	NX_P48052
Antibodypedia	CPA2 antibodies

PROTEIN BROWSER

CPA2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPA2-001 ENSP00000222481 ENST00000222481	P48052 [Direct mapping] Carboxypeptidase A2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005773 [vacuole] GO:0006508 [proteolysis] GO:0007039 [protein catabolic process in the vacuole] GO:0008270 [zinc ion binding] Show all	419 aa 47 kDa	Yes	0