Expression of GDPD5 in cancer - Summary - The Human Protein Atlas

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GDPD5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GDPD5
Gene description	Glycerophosphodiester phosphodiesterase domain containing 5
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HDLM-2)
HPA (normal tissue):	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several tissues along with neuropil expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA065257 , HPA066762
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA065257	HPA066762

GENE INFORMATION
Gene name	GDPD5 (HGNC Symbol)
Synonyms	GDE2, PP1665
Description	Glycerophosphodiester phosphodiesterase domain containing 5 (HGNC Symbol)
Entrez gene summary	Glycerophosphodiester phosphodiesterases (GDPDs; EC 3.1.4.46), such as GDPD5, are involved in glycerol metabolism (Lang et al., 2008 [PubMed 17578682]).[supplied by OMIM, Jan 2010]
Chromosome	11
Cytoband
Chromosome location (bp)	75434640 - 75525903
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158555 (version 83.38)
Entrez gene	81544
UniProt	Q8WTR4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WTR4
Antibodypedia	GDPD5 antibodies

PROTEIN BROWSER

GDPD5-001	GDPD5-003	GDPD5-004	GDPD5-007	GDPD5-008	GDPD5-011	GDPD5-015	GDPD5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GDPD5-001 ENSP00000337972 ENST00000336898	Q8WTR4 [Direct mapping] Glycerophosphodiester phosphodiesterase domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] GO:0008889 [glycerophosphodiester phosphodiesterase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0021522 [spinal cord motor neuron differentiation] GO:0021895 [cerebral cortex neuron differentiation] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031175 [neuron projection development] GO:0043025 [neuronal cell body] GO:0045666 [positive regulation of neuron differentiation] GO:0045787 [positive regulation of cell cycle] GO:0047389 [glycerophosphocholine phosphodiesterase activity] GO:0048505 [regulation of timing of cell differentiation] GO:0097038 [perinuclear endoplasmic reticulum] Show all	605 aa 68.6 kDa	No	6
GDPD5-003 ENSP00000433214 ENST00000529721	Q8WTR4 [Direct mapping] Glycerophosphodiester phosphodiesterase domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] GO:0008889 [glycerophosphodiester phosphodiesterase activity] GO:0016021 [integral component of membrane] GO:0030426 [growth cone] Show all	605 aa 68.6 kDa	No	6
GDPD5-004 ENSP00000437049 ENST00000533784	Q8WTR4 [Direct mapping] Glycerophosphodiester phosphodiesterase domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] GO:0008889 [glycerophosphodiester phosphodiesterase activity] GO:0016021 [integral component of membrane] GO:0030426 [growth cone] Show all	486 aa 54.5 kDa	No	3
GDPD5-007 ENSP00000434050 ENST00000526177	Q8WTR4 [Direct mapping] Glycerophosphodiester phosphodiesterase domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] GO:0008889 [glycerophosphodiester phosphodiesterase activity] GO:0016021 [integral component of membrane] GO:0030426 [growth cone] Show all	467 aa 52.1 kDa	No	3
GDPD5-008 ENSP00000435196 ENST00000533805	Q8WTR4 [Direct mapping] Glycerophosphodiester phosphodiesterase domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] GO:0008889 [glycerophosphodiester phosphodiesterase activity] GO:0016021 [integral component of membrane] GO:0030426 [growth cone] Show all	360 aa 40.6 kDa	No	1
GDPD5-011 ENSP00000433727 ENST00000532435	E9PJU5 [Direct mapping] Glycerophosphodiester phosphodiesterase domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008889 [glycerophosphodiester phosphodiesterase activity] GO:0016021 [integral component of membrane] Show all	73 aa 9.2 kDa	No	1
GDPD5-015 ENSP00000435728 ENST00000534322	H0YEF5 [Direct mapping] Glycerophosphodiester phosphodiesterase domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] GO:0008889 [glycerophosphodiester phosphodiesterase activity] GO:0016021 [integral component of membrane] Show all	176 aa 19.9 kDa	No	1
GDPD5-201 ENSP00000396535 ENST00000443276	Q8NDN3 [Direct mapping] Glycerophosphodiester phosphodiesterase domain-containing protein 5; Putative uncharacterized protein DKFZp434D0316 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008889 [glycerophosphodiester phosphodiesterase activity] GO:0016021 [integral component of membrane] Show all	135 aa 16.2 kDa	No	2

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