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PFKFB1

GENERAL INFORMATION

Gene name

 PFKFB1

Gene description

 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (Hep G2)
HPA (normal tissue):Group enriched (adipose tissue, liver, skeletal muscle)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PFKFB1 (HGNC Symbol)

Synonyms

 PFRX

Description

 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

Chromosome

 X

Cytoband

 p11.21

Chromosome location (bp)

 54932961 - 54998534

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158571 (version 83.38)

Entrez gene

 5207

UniProt

 P16118 (UniProt - Evidence at protein level)

neXtProt

 NX_P16118

Antibodypedia

 PFKFB1 antibodies

PROTEIN BROWSER
PFKFB1-001
PFKFB1-201
PFKFB1-202
PFKFB1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PFKFB1-001
ENSP00000364145
ENST00000375006
P16118 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase
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Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006112 [energy reserve metabolic process]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0019900 [kinase binding]
GO:0031100 [organ regeneration]
GO:0032868 [response to insulin]
GO:0033133 [positive regulation of glucokinase activity]
GO:0033762 [response to glucagon]
GO:0035556 [intracellular signal transduction]
GO:0042594 [response to starvation]
GO:0042802 [identical protein binding]
GO:0043540 [6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0051384 [response to glucocorticoid]
GO:0051591 [response to cAMP]
GO:0061621 [canonical glycolysis]
GO:0070095 [fructose-6-phosphate binding]
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 471 aa
54.7 kDa 		No 0
PFKFB1-201
ENSP00000364131
ENST00000374992
Q4VBA9 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; PFKFB1 protein
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Predicted intracellular proteins
Show all
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0005524 [ATP binding]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0046835 [carbohydrate phosphorylation]
Show all
 271 aa
31.4 kDa 		No 0
PFKFB1-202
ENSP00000444074
ENST00000545676
P16118 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
Predicted intracellular proteins
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006112 [energy reserve metabolic process]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0043540 [6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex]
GO:0044281 [small molecule metabolic process]
GO:0061621 [canonical glycolysis]
Show all
 406 aa
47.4 kDa 		No 0
PFKFB1-203
ENSP00000480232
ENST00000614686
I1Z9G3 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1 splice variant 3; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
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Predicted intracellular proteins
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity]
GO:0005524 [ATP binding]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0046835 [carbohydrate phosphorylation]
Show all
 244 aa
28.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.