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NPM2

GENERAL INFORMATION

Gene name

 NPM2

Gene description

 Nucleophosmin/nucleoplasmin 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (thyroid cancer)
HPA (cell line):Cell line enhanced (HaCaT, HEL, Hep G2)
HPA (normal tissue):Tissue enhanced (parathyroid gland, thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several different tissues types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA041070
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041070

GENE INFORMATION

Gene name

 NPM2

Synonyms

Description

 Nucleophosmin/nucleoplasmin 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 8

Cytoband

 p21.3

Chromosome location (bp)

 22024125 - 22036897

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158806 (version 83.38)

Entrez gene

 10361

UniProt

 Q86SE8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86SE8

Antibodypedia

 NPM2 antibodies

PROTEIN BROWSER
NPM2-001
NPM2-002
NPM2-003
NPM2-004
NPM2-005
NPM2-007
NPM2-009
NPM2-201
NPM2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NPM2-001
ENSP00000381032
ENST00000397940
Q86SE8 [Direct mapping]
Nucleoplasmin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000789 [cytoplasmic chromatin]
GO:0000790 [nuclear chromatin]
GO:0003676 [nucleic acid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0007096 [regulation of exit from mitosis]
GO:0007338 [single fertilization]
GO:0009790 [embryo development]
GO:0009994 [oocyte differentiation]
GO:0019899 [enzyme binding]
GO:0042393 [histone binding]
GO:0043085 [positive regulation of catalytic activity]
GO:0045740 [positive regulation of DNA replication]
GO:0045836 [positive regulation of meiotic nuclear division]
GO:0051054 [positive regulation of DNA metabolic process]
GO:0051260 [protein homooligomerization]
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 214 aa
24.2 kDa 		No 0
NPM2-002
ENSP00000429413
ENST00000521157
Q86SE8 [Direct mapping]
Nucleoplasmin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000789 [cytoplasmic chromatin]
GO:0000790 [nuclear chromatin]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0007096 [regulation of exit from mitosis]
GO:0007338 [single fertilization]
GO:0009790 [embryo development]
GO:0009994 [oocyte differentiation]
GO:0042393 [histone binding]
GO:0045836 [positive regulation of meiotic nuclear division]
Show all
 214 aa
24.2 kDa 		No 0
NPM2-003
ENSP00000427741
ENST00000518119
Q86SE8 [Direct mapping]
Nucleoplasmin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000789 [cytoplasmic chromatin]
GO:0000790 [nuclear chromatin]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0007096 [regulation of exit from mitosis]
GO:0007338 [single fertilization]
GO:0009790 [embryo development]
GO:0009994 [oocyte differentiation]
GO:0042393 [histone binding]
GO:0045836 [positive regulation of meiotic nuclear division]
Show all
 214 aa
24.2 kDa 		No 0
NPM2-004
ENSP00000289820
ENST00000289820
Q86SE8 [Direct mapping]
Nucleoplasmin-2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000789 [cytoplasmic chromatin]
GO:0000790 [nuclear chromatin]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0007096 [regulation of exit from mitosis]
GO:0007338 [single fertilization]
GO:0009790 [embryo development]
GO:0009994 [oocyte differentiation]
GO:0042393 [histone binding]
GO:0045836 [positive regulation of meiotic nuclear division]
Show all
 214 aa
24.2 kDa 		No 0
NPM2-005
ENSP00000370941
ENST00000381530
Q86SE8 [Direct mapping]
Nucleoplasmin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000789 [cytoplasmic chromatin]
GO:0000790 [nuclear chromatin]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0007096 [regulation of exit from mitosis]
GO:0007338 [single fertilization]
GO:0009790 [embryo development]
GO:0009994 [oocyte differentiation]
GO:0042393 [histone binding]
GO:0045836 [positive regulation of meiotic nuclear division]
Show all
 136 aa
15.2 kDa 		No 0
NPM2-007
ENSP00000429984
ENST00000520125
E5RGN1 [Direct mapping]
Nucleoplasmin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
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 99 aa
11.1 kDa 		No 0
NPM2-009
ENSP00000428016
ENST00000522813
E5RFQ8 [Direct mapping]
Nucleoplasmin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
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 137 aa
15.3 kDa 		No 0
NPM2-201
ENSP00000481018
ENST00000615914
Q86SE8 [Direct mapping]
Nucleoplasmin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000789 [cytoplasmic chromatin]
GO:0000790 [nuclear chromatin]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0007096 [regulation of exit from mitosis]
GO:0007338 [single fertilization]
GO:0009790 [embryo development]
GO:0009994 [oocyte differentiation]
GO:0042393 [histone binding]
GO:0045836 [positive regulation of meiotic nuclear division]
Show all
 136 aa
15.2 kDa 		No 0
NPM2-202
ENSP00000481077
ENST00000621538
Q86SE8 [Direct mapping]
Nucleoplasmin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000789 [cytoplasmic chromatin]
GO:0000790 [nuclear chromatin]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0007096 [regulation of exit from mitosis]
GO:0007338 [single fertilization]
GO:0009790 [embryo development]
GO:0009994 [oocyte differentiation]
GO:0042393 [histone binding]
GO:0045836 [positive regulation of meiotic nuclear division]
Show all
 214 aa
24.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.