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A majority of prostate and thyroid cancer as well as several colorectal, ovarian, breast, endometrial, urothelial and liver cancers displayed moderate cytoplasmic staining. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
DMTN (HGNC Symbol)
Synonyms
DMT, EPB49
Description
Dematin actin binding protein (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]