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DMTN

GENERAL INFORMATION

Gene name

 DMTN

Gene description

 Dematin actin binding protein

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 20
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HEL)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA024290
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and glioma (unfavourable).
Renal cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024290

GENE INFORMATION

Gene name

 DMTN (HGNC Symbol)

Synonyms

 DMT, EPB49

Description

 Dematin actin binding protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]

Chromosome

 8

Cytoband

 p21.3

Chromosome location (bp)

 22048995 - 22082527

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158856 (version 83.38)

Entrez gene

 2039

UniProt

 Q08495 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08495

Antibodypedia

 DMTN antibodies

PROTEIN BROWSER
«
DMTN-001
DMTN-004
DMTN-007
DMTN-008
DMTN-009
DMTN-010
DMTN-011
DMTN-012
DMTN-013
DMTN-015
DMTN-016
DMTN-017
DMTN-018
DMTN-019
DMTN-021
DMTN-022
DMTN-201
DMTN-202
DMTN-203
DMTN-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DMTN-001
ENSP00000265800
ENST00000265800
Q08495 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010763 [positive regulation of fibroblast migration]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0012505 [endomembrane system]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030194 [positive regulation of blood coagulation]
GO:0030507 [spectrin binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0031253 [cell projection membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0043621 [protein self-association]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048821 [erythrocyte development]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0051017 [actin filament bundle assembly]
GO:0051489 [regulation of filopodium assembly]
GO:0051693 [actin filament capping]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0055085 [transmembrane transport]
GO:0070560 [protein secretion by platelet]
GO:0071277 [cellular response to calcium ion]
GO:0071320 [cellular response to cAMP]
GO:0090303 [positive regulation of wound healing]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0090527 [actin filament reorganization]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901731 [positive regulation of platelet aggregation]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 405 aa
45.5 kDa 		No 0
DMTN-004
ENSP00000397904
ENST00000443491
Q08495 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010763 [positive regulation of fibroblast migration]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0012505 [endomembrane system]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030194 [positive regulation of blood coagulation]
GO:0030507 [spectrin binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0031253 [cell projection membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0043621 [protein self-association]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048821 [erythrocyte development]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0051017 [actin filament bundle assembly]
GO:0051489 [regulation of filopodium assembly]
GO:0051693 [actin filament capping]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0055085 [transmembrane transport]
GO:0070560 [protein secretion by platelet]
GO:0071277 [cellular response to calcium ion]
GO:0071320 [cellular response to cAMP]
GO:0090303 [positive regulation of wound healing]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0090527 [actin filament reorganization]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901731 [positive regulation of platelet aggregation]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 358 aa
40.7 kDa 		No 0
DMTN-007
ENSP00000430618
ENST00000517600
Q08495 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010763 [positive regulation of fibroblast migration]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0012505 [endomembrane system]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030194 [positive regulation of blood coagulation]
GO:0030507 [spectrin binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0031253 [cell projection membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0043621 [protein self-association]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048821 [erythrocyte development]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0051017 [actin filament bundle assembly]
GO:0051489 [regulation of filopodium assembly]
GO:0051693 [actin filament capping]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0055085 [transmembrane transport]
GO:0070560 [protein secretion by platelet]
GO:0071277 [cellular response to calcium ion]
GO:0071320 [cellular response to cAMP]
GO:0090303 [positive regulation of wound healing]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0090527 [actin filament reorganization]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901731 [positive regulation of platelet aggregation]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 365 aa
41.6 kDa 		No 0
DMTN-008
ENSP00000401291
ENST00000415253
Q08495 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010763 [positive regulation of fibroblast migration]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0012505 [endomembrane system]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030194 [positive regulation of blood coagulation]
GO:0030507 [spectrin binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0031253 [cell projection membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0043621 [protein self-association]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048821 [erythrocyte development]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0051017 [actin filament bundle assembly]
GO:0051489 [regulation of filopodium assembly]
GO:0051693 [actin filament capping]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0055085 [transmembrane transport]
GO:0070560 [protein secretion by platelet]
GO:0071277 [cellular response to calcium ion]
GO:0071320 [cellular response to cAMP]
GO:0090303 [positive regulation of wound healing]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0090527 [actin filament reorganization]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901731 [positive regulation of platelet aggregation]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 383 aa
43.1 kDa 		No 0
DMTN-009
ENSP00000427866
ENST00000523266
Q08495 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010763 [positive regulation of fibroblast migration]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0012505 [endomembrane system]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030194 [positive regulation of blood coagulation]
GO:0030507 [spectrin binding]
GO:0030863 [cortical cytoskeleton]
GO:0031095 [platelet dense tubular network membrane]
GO:0031253 [cell projection membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0043621 [protein self-association]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048821 [erythrocyte development]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0051017 [actin filament bundle assembly]
GO:0051489 [regulation of filopodium assembly]
GO:0051693 [actin filament capping]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0055085 [transmembrane transport]
GO:0070560 [protein secretion by platelet]
GO:0071277 [cellular response to calcium ion]
GO:0071320 [cellular response to cAMP]
GO:0090303 [positive regulation of wound healing]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0090527 [actin filament reorganization]
GO:0097481 [neuronal postsynaptic density]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901731 [positive regulation of platelet aggregation]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 405 aa
45.5 kDa 		No 0
DMTN-010
ENSP00000429377
ENST00000519907
Q08495 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010763 [positive regulation of fibroblast migration]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0012505 [endomembrane system]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030194 [positive regulation of blood coagulation]
GO:0030507 [spectrin binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0031253 [cell projection membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0043621 [protein self-association]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048821 [erythrocyte development]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0051017 [actin filament bundle assembly]
GO:0051489 [regulation of filopodium assembly]
GO:0051693 [actin filament capping]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0055085 [transmembrane transport]
GO:0070560 [protein secretion by platelet]
GO:0071277 [cellular response to calcium ion]
GO:0071320 [cellular response to cAMP]
GO:0090303 [positive regulation of wound healing]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0090527 [actin filament reorganization]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901731 [positive regulation of platelet aggregation]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 383 aa
43.1 kDa 		No 0
DMTN-011
ENSP00000429234
ENST00000523782
Q08495 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010763 [positive regulation of fibroblast migration]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0012505 [endomembrane system]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030194 [positive regulation of blood coagulation]
GO:0030507 [spectrin binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0031253 [cell projection membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0043621 [protein self-association]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048821 [erythrocyte development]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0051017 [actin filament bundle assembly]
GO:0051489 [regulation of filopodium assembly]
GO:0051693 [actin filament capping]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0055085 [transmembrane transport]
GO:0070560 [protein secretion by platelet]
GO:0071277 [cellular response to calcium ion]
GO:0071320 [cellular response to cAMP]
GO:0090303 [positive regulation of wound healing]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0090527 [actin filament reorganization]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901731 [positive regulation of platelet aggregation]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 358 aa
40.7 kDa 		No 0
DMTN-012
ENSP00000428063
ENST00000522148
E5RFK6 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 72 aa
8.3 kDa 		No 0
DMTN-013
ENSP00000429116
ENST00000523300
E5RJC0 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 162 aa
18.2 kDa 		No 0
DMTN-015
ENSP00000430600
ENST00000519850
E5RJ61 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 110 aa
12.1 kDa 		No 0
DMTN-016
ENSP00000428733
ENST00000523623
E5RGQ7 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 148 aa
16.8 kDa 		No 0
DMTN-017
ENSP00000430382
ENST00000520174
E5RFK4 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 218 aa
24.9 kDa 		No 0
DMTN-018
ENSP00000428415
ENST00000517804
E5RGQ0 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 201 aa
22.2 kDa 		No 0
DMTN-019
ENSP00000429948
ENST00000517418
E5RGQ0 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 201 aa
22.2 kDa 		No 0
DMTN-021
ENSP00000478536
ENST00000519333
A0A087WUC0 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 74 aa
8.5 kDa 		No 0
DMTN-022
ENSP00000477684
ENST00000522340
A0A087WT94 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 72 aa
7.9 kDa 		No 0
DMTN-201
ENSP00000350977
ENST00000358242
Q08495 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010763 [positive regulation of fibroblast migration]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0012505 [endomembrane system]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030194 [positive regulation of blood coagulation]
GO:0030507 [spectrin binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0031253 [cell projection membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0043621 [protein self-association]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048821 [erythrocyte development]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0051017 [actin filament bundle assembly]
GO:0051489 [regulation of filopodium assembly]
GO:0051693 [actin filament capping]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0055085 [transmembrane transport]
GO:0070560 [protein secretion by platelet]
GO:0071277 [cellular response to calcium ion]
GO:0071320 [cellular response to cAMP]
GO:0090303 [positive regulation of wound healing]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0090527 [actin filament reorganization]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901731 [positive regulation of platelet aggregation]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 405 aa
45.5 kDa 		No 0
DMTN-202
ENSP00000370879
ENST00000381470
Q08495 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010763 [positive regulation of fibroblast migration]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0012505 [endomembrane system]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030194 [positive regulation of blood coagulation]
GO:0030507 [spectrin binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0031253 [cell projection membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0043621 [protein self-association]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048821 [erythrocyte development]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0051017 [actin filament bundle assembly]
GO:0051489 [regulation of filopodium assembly]
GO:0051693 [actin filament capping]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0055085 [transmembrane transport]
GO:0070560 [protein secretion by platelet]
GO:0071277 [cellular response to calcium ion]
GO:0071320 [cellular response to cAMP]
GO:0090303 [positive regulation of wound healing]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0090527 [actin filament reorganization]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901731 [positive regulation of platelet aggregation]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 383 aa
43.1 kDa 		No 0
DMTN-203
ENSP00000416111
ENST00000432128
Q08495 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010763 [positive regulation of fibroblast migration]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0012505 [endomembrane system]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030194 [positive regulation of blood coagulation]
GO:0030507 [spectrin binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0031253 [cell projection membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0043621 [protein self-association]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048821 [erythrocyte development]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0051017 [actin filament bundle assembly]
GO:0051489 [regulation of filopodium assembly]
GO:0051693 [actin filament capping]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0055085 [transmembrane transport]
GO:0070560 [protein secretion by platelet]
GO:0071277 [cellular response to calcium ion]
GO:0071320 [cellular response to cAMP]
GO:0090303 [positive regulation of wound healing]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0090527 [actin filament reorganization]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901731 [positive regulation of platelet aggregation]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 405 aa
45.5 kDa 		No 0
DMTN-204
ENSP00000430609
ENST00000517305
Q08495 [Direct mapping]
Dematin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010763 [positive regulation of fibroblast migration]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0012505 [endomembrane system]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030194 [positive regulation of blood coagulation]
GO:0030507 [spectrin binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0031253 [cell projection membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0043621 [protein self-association]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048821 [erythrocyte development]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0051017 [actin filament bundle assembly]
GO:0051489 [regulation of filopodium assembly]
GO:0051693 [actin filament capping]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0055085 [transmembrane transport]
GO:0070560 [protein secretion by platelet]
GO:0071277 [cellular response to calcium ion]
GO:0071320 [cellular response to cAMP]
GO:0090303 [positive regulation of wound healing]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0090527 [actin filament reorganization]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901731 [positive regulation of platelet aggregation]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 405 aa
45.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.