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CCAR2

GENERAL INFORMATION

Gene name

 CCAR2

Gene description

 Cell cycle and apoptosis regulator 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA019907 , HPA019943 , CAB072827
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019907
HPA019943
CAB072827

GENE INFORMATION

Gene name

 CCAR2 (HGNC Symbol)

Synonyms

 DBC-1, DBC1, KIAA1967, NET35

Description

 Cell cycle and apoptosis regulator 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 8

Cytoband

 p21.3

Chromosome location (bp)

 22604632 - 22621514

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158941 (version 83.38)

Entrez gene

 57805

UniProt

 Q8N163 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N163

Antibodypedia

 CCAR2 antibodies

PROTEIN BROWSER
«
CCAR2-001
CCAR2-002
CCAR2-003
CCAR2-004
CCAR2-005
CCAR2-006
CCAR2-007
CCAR2-009
CCAR2-011
CCAR2-013
CCAR2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCAR2-001
ENSP00000310670
ENST00000308511
Q8N163 [Direct mapping]
Cell cycle and apoptosis regulator protein 2
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000993 [RNA polymerase II core binding]
GO:0004857 [enzyme inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0008380 [RNA splicing]
GO:0009411 [response to UV]
GO:0016055 [Wnt signaling pathway]
GO:0019899 [enzyme binding]
GO:0030308 [negative regulation of cell growth]
GO:0031647 [regulation of protein stability]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032784 [regulation of DNA-templated transcription, elongation]
GO:0034605 [cellular response to heat]
GO:0042752 [regulation of circadian rhythm]
GO:0043065 [positive regulation of apoptotic process]
GO:0043086 [negative regulation of catalytic activity]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0044609 [DBIRD complex]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048511 [rhythmic process]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090311 [regulation of protein deacetylation]
GO:1900034 [regulation of cellular response to heat]
GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage]
GO:2000003 [positive regulation of DNA damage checkpoint]
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 923 aa
102.9 kDa 		No 0
CCAR2-002
ENSP00000373930
ENST00000389279
Q8N163 [Direct mapping]
Cell cycle and apoptosis regulator protein 2
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000993 [RNA polymerase II core binding]
GO:0004857 [enzyme inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0008380 [RNA splicing]
GO:0009411 [response to UV]
GO:0016055 [Wnt signaling pathway]
GO:0019899 [enzyme binding]
GO:0030308 [negative regulation of cell growth]
GO:0031647 [regulation of protein stability]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032784 [regulation of DNA-templated transcription, elongation]
GO:0034605 [cellular response to heat]
GO:0042752 [regulation of circadian rhythm]
GO:0043065 [positive regulation of apoptotic process]
GO:0043086 [negative regulation of catalytic activity]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0044609 [DBIRD complex]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048511 [rhythmic process]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090311 [regulation of protein deacetylation]
GO:1900034 [regulation of cellular response to heat]
GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage]
GO:2000003 [positive regulation of DNA damage checkpoint]
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 923 aa
102.9 kDa 		No 0
CCAR2-003
ENSP00000429773
ENST00000520861
G3V119 [Direct mapping]
Cell cycle and apoptosis regulator protein 2; KIAA1967, isoform CRA_b
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008380 [RNA splicing]
GO:0043065 [positive regulation of apoptotic process]
GO:0044609 [DBIRD complex]
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 598 aa
67.3 kDa 		No 0
CCAR2-004
ENSP00000431046
ENST00000518989
H0YC69 [Direct mapping]
Cell cycle and apoptosis regulator protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006355 [regulation of transcription, DNA-templated]
GO:0008380 [RNA splicing]
GO:0043065 [positive regulation of apoptotic process]
GO:0044609 [DBIRD complex]
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 148 aa
16.3 kDa 		No 0
CCAR2-005
ENSP00000430978
ENST00000521837
E5RGU7 [Direct mapping]
Cell cycle and apoptosis regulator protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006355 [regulation of transcription, DNA-templated]
GO:0008380 [RNA splicing]
GO:0043065 [positive regulation of apoptotic process]
GO:0044609 [DBIRD complex]
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 150 aa
16.1 kDa 		No 0
CCAR2-006
ENSP00000428843
ENST00000523349
E5RFJ3 [Direct mapping]
Cell cycle and apoptosis regulator protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006355 [regulation of transcription, DNA-templated]
GO:0008380 [RNA splicing]
GO:0043065 [positive regulation of apoptotic process]
GO:0044609 [DBIRD complex]
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 162 aa
17.5 kDa 		No 0
CCAR2-007
ENSP00000430974
ENST00000523801
H0YC58 [Direct mapping]
Cell cycle and apoptosis regulator protein 2
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008380 [RNA splicing]
GO:0043065 [positive regulation of apoptotic process]
GO:0044609 [DBIRD complex]
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 183 aa
19.3 kDa 		No 0
CCAR2-009
ENSP00000428549
ENST00000520738
H0YB24 [Direct mapping]
Cell cycle and apoptosis regulator protein 2
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008380 [RNA splicing]
GO:0043065 [positive regulation of apoptotic process]
GO:0044609 [DBIRD complex]
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 615 aa
68.8 kDa 		No 0
CCAR2-011
ENSP00000429769
ENST00000521301
E5RHH8 [Direct mapping]
Cell cycle and apoptosis regulator protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006355 [regulation of transcription, DNA-templated]
GO:0008380 [RNA splicing]
GO:0043065 [positive regulation of apoptotic process]
GO:0044609 [DBIRD complex]
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 81 aa
8.9 kDa 		No 0
CCAR2-013
ENSP00000429739
ENST00000522599
E5RHJ4 [Direct mapping]
Cell cycle and apoptosis regulator protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006355 [regulation of transcription, DNA-templated]
GO:0008380 [RNA splicing]
GO:0043065 [positive regulation of apoptotic process]
GO:0044609 [DBIRD complex]
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 277 aa
31.1 kDa 		No 0
CCAR2-201
ENSP00000484850
ENST00000613179
A0A087X2B6 [Direct mapping]
Cell cycle and apoptosis regulator protein 2
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008380 [RNA splicing]
GO:0043065 [positive regulation of apoptotic process]
GO:0044609 [DBIRD complex]
Show all
 272 aa
30.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.