Expression of ALG8 in cancer - Summary - The Human Protein Atlas

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ALG8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ALG8
Gene description	ALG8, alpha-1,3-glucosyltransferase
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in several different cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA051898
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051898

GENE INFORMATION
Gene name	ALG8 (HGNC Symbol)
Synonyms	MGC2840
Description	ALG8, alpha-1,3-glucosyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation of proteins. Mutations in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ih). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q14.1
Chromosome location (bp)	78100936 - 78139660
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159063 (version 83.38)
Entrez gene	79053
UniProt	Q9BVK2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BVK2
Antibodypedia	ALG8 antibodies

PROTEIN BROWSER

ALG8-001	ALG8-005	ALG8-008	ALG8-009	ALG8-010	ALG8-011	ALG8-012	ALG8-014	ALG8-015	ALG8-016	ALG8-018	ALG8-019	ALG8-020	ALG8-021	ALG8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALG8-001 ENSP00000299626 ENST00000299626	Q9BVK2 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase A0A024R5K5 [Target identity:100%; Query identity:100%] Asparagine-linked glycosylation 8 homolog (Yeast, alpha-1,3-glucosyltransferase), isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000033 [alpha-1,3-mannosyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006487 [protein N-linked glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097502 [mannosylation] Show all	526 aa 60.1 kDa	No	>9
ALG8-005 ENSP00000365326 ENST00000376156	Q9BVK2 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000033 [alpha-1,3-mannosyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006487 [protein N-linked glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097502 [mannosylation] Show all	467 aa 53.2 kDa	No	>9
ALG8-008 ENSP00000431357 ENST00000525761	E9PLP7 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] Show all	96 aa 11.7 kDa	No	1
ALG8-009 ENSP00000436064 ENST00000527099	E9PR58 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] Show all	136 aa 15.9 kDa	No	3
ALG8-010 ENSP00000435467 ENST00000525755	E9PK79 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] Show all	242 aa 28.3 kDa	No	5
ALG8-011 ENSP00000435417 ENST00000525870	E9PKA5 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] Show all	172 aa 19.8 kDa	No	5
ALG8-012 ENSP00000434660 ENST00000530454	E9PP96 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] Show all	282 aa 32.7 kDa	No	5
ALG8-014 ENSP00000437033 ENST00000530910	E9PP04 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] Show all	126 aa 15.1 kDa	No	1
ALG8-015 ENSP00000435626 ENST00000532306	H0YEE0 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] Show all	282 aa 32.1 kDa	No	8
ALG8-016 ENSP00000433429 ENST00000532440	H0YDD3 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] Show all	226 aa 25.5 kDa	No	4
ALG8-018 ENSP00000432381 ENST00000530608	H0YCV0 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] Show all	228 aa 25.6 kDa	Yes	8
ALG8-019 ENSP00000434388 ENST00000526849	H0YDV4 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] Show all	197 aa 22.1 kDa	No	7
ALG8-020 ENSP00000432953 ENST00000529139	H0YD42 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] Show all	157 aa 18 kDa	No	4
ALG8-021 ENSP00000434066 ENST00000525783	H0YDQ1 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] Show all	87 aa 9.7 kDa	No	1
ALG8-201 ENSP00000480742 ENST00000615266	Q9BVK2 [Direct mapping] Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000033 [alpha-1,3-mannosyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006487 [protein N-linked glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006490 [oligosaccharide-lipid intermediate biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0042281 [dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097502 [mannosylation] Show all	467 aa 53.2 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.