Cell atlas - C21orf59 - The Human Protein Atlas

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C21orf59

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Rods & Rings

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	C21orf59
Gene description	Chromosome 21 open reading frame 59
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the rods & rings.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Rods & Rings (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB034170
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the rods & rings.

Main location

Rods & Rings (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB034170	U-2 OS	No staining
	CAB034170	U-251 MG	Rods & Rings

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	CAB034170	U-2 OS	Image	U-2 OS cells were treated with Ribavirin to induce the formation of Rods & Rings. Co-localization shows that C21orf59 localizes to Rods & Rings as the staining overlaps with a marker for Rods & Rings.

GENE INFORMATION
Gene name	C21orf59 (HGNC Symbol)
Synonyms	C21orf48, CILD26, FBB18, FLJ20467
Description	Chromosome 21 open reading frame 59 (HGNC Symbol)
Entrez gene summary	This gene a protein plays a critical role in dynein arm assembly and motile cilia function. Mutations in this gene result in primary ciliary dyskinesia. [provided by RefSeq, Nov 2013]
Chromosome	21
Cytoband	q22.11
Chromosome location (bp)	32592079 - 32612866
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159079 (version 83.38)
Entrez gene	56683
UniProt	P57076 (UniProt - Evidence at protein level)
neXtProt	NX_P57076
Antibodypedia	C21orf59 antibodies

PROTEIN BROWSER

C21orf59-001	C21orf59-002	C21orf59-004	C21orf59-005	C21orf59-006	C21orf59-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C21orf59-001 ENSP00000290155 ENST00000290155	P57076 [Direct mapping] UPF0769 protein C21orf59 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0048858 [cell projection morphogenesis] Show all	290 aa 33.2 kDa	No	0
C21orf59-002 ENSP00000371989 ENST00000382549	D3DSE6 [Direct mapping] Chromosome 21 open reading frame 59, isoform CRA_b; UPF0769 protein C21orf59 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		245 aa 27.6 kDa	No	0
C21orf59-004 ENSP00000407362 ENST00000425336	H7C2R6 [Direct mapping] UPF0769 protein C21orf59 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		117 aa 13.3 kDa	No	0
C21orf59-005 ENSP00000411306 ENST00000431599	H7C3D9 [Direct mapping] UPF0769 protein C21orf59 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		79 aa 8.5 kDa	No	0
C21orf59-006 ENSP00000411467 ENST00000440966	C9J818 [Direct mapping] UPF0769 protein C21orf59 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		258 aa 29.4 kDa	No	0
C21orf59-007 ENSP00000393104 ENST00000458138	C9JX57 [Direct mapping] UPF0769 protein C21orf59 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		184 aa 20.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.