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SYNJ1

GENERAL INFORMATION

Gene name

 SYNJ1

Gene description

 Synaptojanin 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types, most abundant in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Supported based on 1 antibody.
HPA011916
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SYNJ1 (HGNC Symbol)

Synonyms

 INPP5G, PARK20

Description

 Synaptojanin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 21

Cytoband

 q22.11

Chromosome location (bp)

 32628759 - 32728048

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159082 (version 83.38)

Entrez gene

 8867

UniProt

 O43426 (UniProt - Evidence at protein level)

neXtProt

 NX_O43426

Antibodypedia

 SYNJ1 antibodies

PROTEIN BROWSER
SYNJ1-001
SYNJ1-002
SYNJ1-003
SYNJ1-004
SYNJ1-006
SYNJ1-009
SYNJ1-014
SYNJ1-201
SYNJ1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYNJ1-001
ENSP00000371939
ENST00000382499
C9JFZ1 [Direct mapping]
Synaptojanin-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0042578 [phosphoric ester hydrolase activity]
GO:0046856 [phosphatidylinositol dephosphorylation]
Show all
 1350 aa
149.3 kDa 		No 0
SYNJ1-002
ENSP00000413649
ENST00000429236
C9JW66 [Direct mapping]
Synaptojanin-1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0042578 [phosphoric ester hydrolase activity]
GO:0046856 [phosphatidylinositol dephosphorylation]
Show all
 695 aa
77.6 kDa 		No 0
SYNJ1-003
ENSP00000388869
ENST00000438952
H7BZC2 [Direct mapping]
Synaptojanin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 187 aa
19.2 kDa 		No 0
SYNJ1-004
ENSP00000409667
ENST00000433931
J3KQV8 [Direct mapping]
Synaptojanin-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0004439 [phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006836 [neurotransmitter transport]
GO:0007420 [brain development]
GO:0007612 [learning]
GO:0008022 [protein C-terminus binding]
GO:0014015 [positive regulation of gliogenesis]
GO:0016082 [synaptic vesicle priming]
GO:0016191 [synaptic vesicle uncoating]
GO:0017124 [SH3 domain binding]
GO:0030117 [membrane coat]
GO:0032403 [protein complex binding]
GO:0032526 [response to retinoic acid]
GO:0034097 [response to cytokine]
GO:0034595 [phosphatidylinositol phosphate 5-phosphatase activity]
GO:0042578 [phosphoric ester hydrolase activity]
GO:0043005 [neuron projection]
GO:0043234 [protein complex]
GO:0046855 [inositol phosphate dephosphorylation]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0048260 [positive regulation of receptor-mediated endocytosis]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048489 [synaptic vesicle transport]
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 1612 aa
177.5 kDa 		No 0
SYNJ1-006
ENSP00000412707
ENST00000456084
C9J1Z6 [Direct mapping]
Synaptojanin-1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0042578 [phosphoric ester hydrolase activity]
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 178 aa
20.2 kDa 		No 0
SYNJ1-009
ENSP00000387868
ENST00000418301
H7BZ56 [Direct mapping]
Synaptojanin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 131 aa
13.3 kDa 		No 0
SYNJ1-014
ENSP00000487560
ENST00000630077
A0A0D9SGJ6 [Direct mapping]
Synaptojanin-1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0042578 [phosphoric ester hydrolase activity]
GO:0046856 [phosphatidylinositol dephosphorylation]
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 1526 aa
168.2 kDa 		No 0
SYNJ1-201
ENSP00000349903
ENST00000357345
O43426 [Direct mapping]
Synaptojanin-1
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0004439 [phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity]
GO:0004445 [inositol-polyphosphate 5-phosphatase activity]
GO:0005829 [cytosol]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0006836 [neurotransmitter transport]
GO:0016082 [synaptic vesicle priming]
GO:0016191 [synaptic vesicle uncoating]
GO:0030117 [membrane coat]
GO:0034595 [phosphatidylinositol phosphate 5-phosphatase activity]
GO:0042578 [phosphoric ester hydrolase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046855 [inositol phosphate dephosphorylation]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048489 [synaptic vesicle transport]
GO:1901632 [regulation of synaptic vesicle membrane organization]
GO:1903390 [positive regulation of synaptic vesicle uncoating]
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 1295 aa
143.3 kDa 		No 0
SYNJ1-202
ENSP00000371931
ENST00000382491
J3KPK1 [Direct mapping]
Synaptojanin-1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0042578 [phosphoric ester hydrolase activity]
GO:0046856 [phosphatidylinositol dephosphorylation]
Show all
 1264 aa
139.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.