Expression of MRPL10 in cancer - Summary - The Human Protein Atlas

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MRPL10

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MRPL10
Gene description	Mitochondrial ribosomal protein L10
Protein class	Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA021234 , HPA029885
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021234	HPA029885

GENE INFORMATION
Gene name	MRPL10 (HGNC Symbol)
Synonyms	L10MT, MGC17973, MRP-L10, MRP-L8, MRPL8, RPML8
Description	Mitochondrial ribosomal protein L10 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	47823272 - 47831534
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159111 (version 83.38)
Entrez gene	124995
UniProt	Q7Z7H8 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z7H8
Antibodypedia	MRPL10 antibodies

PROTEIN BROWSER

MRPL10-001	MRPL10-002	MRPL10-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL10-001 ENSP00000324100 ENST00000351111	Q7Z7H8 [Direct mapping] 39S ribosomal protein L10, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0030529 [ribonucleoprotein complex] GO:0032543 [mitochondrial translation] GO:0042254 [ribosome biogenesis] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	261 aa 29.3 kDa	No	0
MRPL10-002 ENSP00000395870 ENST00000414011	Q7Z7H8 [Direct mapping] 39S ribosomal protein L10, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0030529 [ribonucleoprotein complex] GO:0032543 [mitochondrial translation] GO:0042254 [ribosome biogenesis] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	271 aa 30.3 kDa	No	0
MRPL10-003 ENSP00000290208 ENST00000290208	Q7Z7H8 [Direct mapping] 39S ribosomal protein L10, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0030529 [ribonucleoprotein complex] GO:0032543 [mitochondrial translation] GO:0042254 [ribosome biogenesis] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	271 aa 30.3 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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