Expression of DONSON in cancer - Summary - The Human Protein Atlas

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DONSON

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DONSON
Gene description	Downstream neighbor of SON
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, including testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 2 antibodies. HPA039558 , HPA049033
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), ovarian cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039558	HPA049033

GENE INFORMATION
Gene name	DONSON (HGNC Symbol)
Synonyms	B17, C21orf60, C2TA, DKFZP434M035
Description	Downstream neighbor of SON (HGNC Symbol)
Entrez gene summary	This gene lies downstream of the SON gene and spans 10 kb on chromosome 21. The function of this gene is unknown. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q22.11
Chromosome location (bp)	33559542 - 33588708
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159147 (version 83.38)
Entrez gene	29980
UniProt	Q9NYP3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NYP3
Antibodypedia	DONSON antibodies

PROTEIN BROWSER

DONSON-001	DONSON-002	DONSON-008	DONSON-009	DONSON-013	DONSON-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DONSON-001 ENSP00000307143 ENST00000303071	Q9NYP3 [Direct mapping] Protein downstream neighbor of Son Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0007275 [multicellular organismal development] GO:0008150 [biological_process] Show all	566 aa 62.7 kDa	No	0
DONSON-002 ENSP00000399535 ENST00000437395	H7C1C1 [Direct mapping] Protein downstream neighbor of Son Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		537 aa 59.2 kDa	No	0
DONSON-008 ENSP00000304716 ENST00000303113	F8W8A5 [Direct mapping] Protein downstream neighbor of Son Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		552 aa 61.1 kDa	No	0
DONSON-009 ENSP00000401082 ENST00000440810	H7C1M7 [Direct mapping] Protein downstream neighbor of Son Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		235 aa 26.3 kDa	No	0
DONSON-013 ENSP00000398329 ENST00000432378	C9J4K5 [Direct mapping] Protein downstream neighbor of Son Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		495 aa 54.9 kDa	No	0
DONSON-014 ENSP00000394276 ENST00000453626	C9JSP0 [Direct mapping] Protein downstream neighbor of Son Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		508 aa 56.7 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.