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STC1

GENERAL INFORMATION

Gene name

 STC1

Gene description

 Stanniocalcin 1

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cervix, uterine)
GTEx:Tissue enhanced (thyroid gland)
FANTOM5:Tissue enhanced (adipose tissue)

Protein evidence

 Evidence at protein level

Protein expression

 Positivity in plasma and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 2 antibodies.
HPA023918 , CAB018625
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue)

GENE INFORMATION

Gene name

 STC1 (HGNC Symbol)

Synonyms

 STC

Description

 Stanniocalcin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 p21.2

Chromosome location (bp)

 23841915 - 23854807

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159167 (version 83.38)

Entrez gene

 6781

UniProt

 P52823 (UniProt - Evidence at protein level)

neXtProt

 NX_P52823

Antibodypedia

 STC1 antibodies

PROTEIN BROWSER
STC1-001
STC1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STC1-001
ENSP00000290271
ENST00000290271
P52823 [Direct mapping]
Stanniocalcin-1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0001886 [endothelial cell morphogenesis]
GO:0003421 [growth plate cartilage axis specification]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007566 [embryo implantation]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0014070 [response to organic cyclic compound]
GO:0016324 [apical plasma membrane]
GO:0030336 [negative regulation of cell migration]
GO:0033280 [response to vitamin D]
GO:0035988 [chondrocyte proliferation]
GO:0044070 [regulation of anion transport]
GO:0046697 [decidualization]
GO:0051926 [negative regulation of calcium ion transport]
GO:0060348 [bone development]
GO:0071320 [cellular response to cAMP]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0071456 [cellular response to hypoxia]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0090280 [positive regulation of calcium ion import]
GO:1903403 [negative regulation of renal phosphate excretion]
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 247 aa
27.6 kDa 		Yes 0
STC1-002
ENSP00000427932
ENST00000524323
P52823 [Direct mapping]
Stanniocalcin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001886 [endothelial cell morphogenesis]
GO:0003421 [growth plate cartilage axis specification]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006874 [cellular calcium ion homeostasis]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0030336 [negative regulation of cell migration]
GO:0035988 [chondrocyte proliferation]
GO:0044070 [regulation of anion transport]
GO:0051926 [negative regulation of calcium ion transport]
GO:0060348 [bone development]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0090280 [positive regulation of calcium ion import]
GO:1903403 [negative regulation of renal phosphate excretion]
Show all
 178 aa
20.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.