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HOXB13

GENERAL INFORMATION

Gene name

 HOXB13

Gene description

 Homeobox B13

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (prostate cancer)
HPA (cell line):Cell line enriched (PC-3)
HPA (normal tissue):Tissue enhanced (prostate, rectum)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in prostate and gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA062852 , HPA065019 , CAB004438
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA062852
HPA065019
CAB004438

GENE INFORMATION

Gene name

 HOXB13

Synonyms

Description

 Homeobox B13 (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.32

Chromosome location (bp)

 48724763 - 48729178

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159184 (version 83.38)

Entrez gene

 10481

UniProt

 Q92826 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92826

Antibodypedia

 HOXB13 antibodies

PROTEIN BROWSER
HOXB13-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HOXB13-001
ENSP00000290295
ENST00000290295
Q92826 [Direct mapping]
Homeobox protein Hox-B13
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis]
GO:0002009 [morphogenesis of an epithelium]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008544 [epidermis development]
GO:0009611 [response to wounding]
GO:0033574 [response to testosterone]
GO:0040008 [regulation of growth]
GO:0043565 [sequence-specific DNA binding]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060743 [epithelial cell maturation involved in prostate gland development]
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 284 aa
30.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.