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KCNE2

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GENERAL INFORMATION

Gene name

 KCNE2

Gene description

 Potassium channel, voltage gated subfamily E regulatory beta subunit 2

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 KCNE2 (HGNC Symbol)

Synonyms

 LQT6, MiRP1

Description

 Potassium channel, voltage gated subfamily E regulatory beta subunit 2 (HGNC Symbol)

Entrez gene summary

 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.11

Chromosome location (bp)

 34364024 - 34371389

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159197 (version 83.38)

Entrez gene

 9992

UniProt

 Q9Y6J6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6J6

Antibodypedia

 KCNE2 antibodies

PROTEIN BROWSER
KCNE2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNE2-001
ENSP00000290310
ENST00000290310
Q9Y6J6 [Direct mapping]
Potassium voltage-gated channel subfamily E member 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0007568 [aging]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009986 [cell surface]
GO:0010107 [potassium ion import]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035690 [cellular response to drug]
GO:0042803 [protein homodimerization activity]
GO:0043586 [tongue development]
GO:0044325 [ion channel binding]
GO:0060306 [regulation of membrane repolarization]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086009 [membrane repolarization]
GO:0086011 [membrane repolarization during action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1901387 [positive regulation of voltage-gated calcium channel activity]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1902159 [regulation of cyclic nucleotide-gated ion channel activity]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:1902282 [voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization]
GO:1903817 [negative regulation of voltage-gated potassium channel activity]
Show all
 123 aa
14.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.