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IGF2BP1

GENERAL INFORMATION

Gene name

 IGF2BP1

Gene description

 Insulin-like growth factor 2 mRNA binding protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (placenta, testis)
GTEx:Tissue enriched (testis)
FANTOM5:Group enriched (placenta, testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in cells in seminiferous ducts of testis and follicle cells in ovary.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA021367 , HPA062273
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (placenta, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (placenta, testis)

GENE INFORMATION

Gene name

 IGF2BP1 (HGNC Symbol)

Synonyms

 IMP-1

Description

 Insulin-like growth factor 2 mRNA binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Chromosome

 17

Cytoband

 q21.32

Chromosome location (bp)

 48997412 - 49055650

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159217 (version 83.38)

Entrez gene

 10642

UniProt

 Q9NZI8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZI8

Antibodypedia

 IGF2BP1 antibodies

PROTEIN BROWSER
IGF2BP1-001
IGF2BP1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IGF2BP1-001
ENSP00000290341
ENST00000290341
Q9NZI8 [Direct mapping]
Insulin-like growth factor 2 mRNA-binding protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006403 [RNA localization]
GO:0010467 [gene expression]
GO:0010494 [cytoplasmic stress granule]
GO:0010610 [regulation of mRNA stability involved in response to stress]
GO:0017148 [negative regulation of translation]
GO:0022013 [pallium cell proliferation in forebrain]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030529 [ribonucleoprotein complex]
GO:0042035 [regulation of cytokine biosynthetic process]
GO:0043197 [dendritic spine]
GO:0044822 [poly(A) RNA binding]
GO:0045182 [translation regulator activity]
GO:0048027 [mRNA 5'-UTR binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051028 [mRNA transport]
GO:0070934 [CRD-mediated mRNA stabilization]
GO:0070937 [CRD-mediated mRNA stability complex]
GO:0097150 [neuronal stem cell population maintenance]
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 577 aa
63.5 kDa 		No 0
IGF2BP1-002
ENSP00000389135
ENST00000431824
Q9NZI8 [Direct mapping]
Insulin-like growth factor 2 mRNA-binding protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0010467 [gene expression]
GO:0010494 [cytoplasmic stress granule]
GO:0010610 [regulation of mRNA stability involved in response to stress]
GO:0017148 [negative regulation of translation]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030529 [ribonucleoprotein complex]
GO:0042035 [regulation of cytokine biosynthetic process]
GO:0043197 [dendritic spine]
GO:0044822 [poly(A) RNA binding]
GO:0045182 [translation regulator activity]
GO:0048027 [mRNA 5'-UTR binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051028 [mRNA transport]
GO:0070934 [CRD-mediated mRNA stabilization]
GO:0070937 [CRD-mediated mRNA stability complex]
Show all
 438 aa
48.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.