Fields »
ABOUT
HELP
BLOG
CBR1

GENERAL INFORMATION

Gene name

 CBR1

Gene description

 Carbonyl reductase 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA018433
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable) and renal cancer (favourable).
Breast cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018433

GENE INFORMATION

Gene name

 CBR1 (HGNC Symbol)

Synonyms

 CBR, SDR21C1

Description

 Carbonyl reductase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

Chromosome

 21

Cytoband

 q22.12

Chromosome location (bp)

 36069941 - 36073166

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159228 (version 83.38)

Entrez gene

 873

UniProt

 P16152 (UniProt - Evidence at protein level)

neXtProt

 NX_P16152

Antibodypedia

 CBR1 antibodies

PROTEIN BROWSER
CBR1-001
CBR1-002
CBR1-003
CBR1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CBR1-001
ENSP00000290349
ENST00000290349
P16152 [Direct mapping]
Carbonyl reductase [NADPH] 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004090 [carbonyl reductase (NADPH) activity]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0017144 [drug metabolic process]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0030855 [epithelial cell differentiation]
GO:0042373 [vitamin K metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047021 [15-hydroxyprostaglandin dehydrogenase (NADP+) activity]
GO:0050221 [prostaglandin-E2 9-reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 277 aa
30.4 kDa 		No 0
CBR1-002
ENSP00000382143
ENST00000399191
A8MTM1 [Direct mapping]
Carbonyl reductase [NADPH] 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 222 aa
24.5 kDa 		No 0
CBR1-003
ENSP00000395132
ENST00000439427
E9PQ63 [Direct mapping]
Carbonyl reductase [NADPH] 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 178 aa
19 kDa 		No 0
CBR1-004
ENSP00000434613
ENST00000530908
P16152 [Direct mapping]
Carbonyl reductase [NADPH] 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004090 [carbonyl reductase (NADPH) activity]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0017144 [drug metabolic process]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0030855 [epithelial cell differentiation]
GO:0042373 [vitamin K metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047021 [15-hydroxyprostaglandin dehydrogenase (NADP+) activity]
GO:0050221 [prostaglandin-E2 9-reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 173 aa
18.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.