Expression of C2orf81 in cancer - Summary

GENERAL INFORMATION
Gene name	C2orf81
Gene description	Chromosome 2 open reading frame 81
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (fallopian tube, testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic and membranous expression in ciliated cells of fallopian tube and endometrium.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA054835
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and pancreatic cancer (favourable).
Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA054835

GENE INFORMATION
Gene name	C2orf81 (HGNC Symbol)
Synonyms	hCG40743, LOC388963
Description	Chromosome 2 open reading frame 81 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p13.1
Chromosome location (bp)	74414176 - 74421591
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000159239 (version 83.38)
Entrez gene	388963
UniProt
neXtProt
Antibodypedia	C2orf81 antibodies

PROTEIN BROWSER

C2orf81-001	C2orf81-002	C2orf81-003	C2orf81-004	C2orf81-201	C2orf81-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C2orf81-001 ENSP00000429388 ENST00000518863	E5RIL7 [Direct mapping] Uncharacterized protein C2orf81 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all		161 aa 16.9 kDa	No	0
C2orf81-002 ENSP00000431103 ENST00000517883	E5RJQ4 [Direct mapping] Uncharacterized protein C2orf81 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all		520 aa 56.1 kDa	No	0
C2orf81-003 ENSP00000430754 ENST00000517896	E5RID8 [Direct mapping] Uncharacterized protein C2orf81 Show all	Predicted intracellular proteins Show all		196 aa 21.3 kDa	No	0
C2orf81-004 ENSP00000430670 ENST00000518401	E5RIT9 [Direct mapping] Uncharacterized protein C2orf81 Show all	Predicted intracellular proteins Show all	GO:0006355 [regulation of transcription, DNA-templated] Show all	109 aa 12.1 kDa	No	0
C2orf81-201 ENSP00000290390 ENST00000290390	G3XAA6 [Direct mapping] HCG40743, isoform CRA_a; Uncharacterized protein C2orf81 Show all	Predicted intracellular proteins Show all		588 aa 64.1 kDa	No	0
C2orf81-202 ENSP00000481409 ENST00000612891	A0A087WXZ4 [Direct mapping] Uncharacterized protein C2orf81 Show all	Predicted intracellular proteins Show all		582 aa 63.2 kDa	No	0