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Moderate cytoplasmic and membranous positivity was observed in several cases of breast, testicular ad urothelial cancer. Remaining malignant cells were in general weakly stained or negative.
Fractions of cells in a few urothelial cancers showed moderate to strong cytoplasmic immunoreactivity. Remaining tumors were basically negative.
GENE INFORMATION
Gene name
ACTC1 (HGNC Symbol)
Synonyms
ACTC, CMD1R
Description
Actin, alpha, cardiac muscle 1 (HGNC Symbol)
Entrez gene summary
Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]