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Gene name

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Chromosome

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In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

Score

Antibodies

Column

 
 
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ACTC1
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ACTC1

Gene description

Actin, alpha, cardiac muscle 1

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (head and neck cancer, prostate cancer, testis cancer, urothelial cancer)
HPA (cell line):Group enriched (LHCN-M2, RH-30)
HPA (normal tissue):Tissue enriched (heart muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in heart, skeletal and smooth muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Supported based on 4 antibodies.
HPA041264 , HPA041271 , CAB003761 , CAB037330
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in head and neck cancer (unfavourable) and urothelial cancer (unfavourable).
Head and neck cancer p<0.001
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (head and neck cancer, prostate cancer, testis cancer, urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA041264
HPA041271
CAB003761
CAB037330

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of cancer tissues showed moderate to strong membranous and/or cytoplasmic positivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Colorectal, ovarian, endometrial, testicular, breast, urothelial, pancreatic and liver cancers displayed moderate to strong membranous staining. Malignant lymphomas exhibited moderate to strong cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate cytoplasmic and membranous positivity was observed in several cases of breast, testicular ad urothelial cancer. Remaining malignant cells were in general weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Fractions of cells in a few urothelial cancers showed moderate to strong cytoplasmic immunoreactivity. Remaining tumors were basically negative.

GENE INFORMATION

Gene name

ACTC1 (HGNC Symbol)

Synonyms

ACTC, CMD1R

Description

Actin, alpha, cardiac muscle 1 (HGNC Symbol)

Entrez gene summary

Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q14

Chromosome location (bp)

34788096 - 34796139

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159251 (version 83.38)

Entrez gene

70

UniProt

P68032 (UniProt - Evidence at protein level)

neXtProt

NX_P68032

Antibodypedia

ACTC1 antibodies

PROTEIN BROWSER

ACTC1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACTC1-001
ENSP00000290378
ENST00000290378
P68032 [Direct mapping]
Actin, alpha cardiac muscle 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0017022 [myosin binding]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030048 [actin filament-based movement]
GO:0030049 [muscle filament sliding]
GO:0030175 [filopodium]
GO:0030240 [skeletal muscle thin filament assembly]
GO:0031032 [actomyosin structure organization]
GO:0031674 [I band]
GO:0033275 [actin-myosin filament sliding]
GO:0042493 [response to drug]
GO:0042643 [actomyosin, actin portion]
GO:0043066 [negative regulation of apoptotic process]
GO:0044297 [cell body]
GO:0045471 [response to ethanol]
GO:0055003 [cardiac myofibril assembly]
GO:0055008 [cardiac muscle tissue morphogenesis]
GO:0060047 [heart contraction]
GO:0060048 [cardiac muscle contraction]
GO:0070062 [extracellular exosome]
GO:0070252 [actin-mediated cell contraction]
GO:0072562 [blood microparticle]
GO:0090131 [mesenchyme migration]
Show all
377 aa
42 kDa
No 0

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