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HLCS

GENERAL INFORMATION

Gene name

 HLCS

Gene description

 Holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA017379
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA017379

GENE INFORMATION

Gene name

 HLCS (HGNC Symbol)

Synonyms

 HCS

Description

 Holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jun 2011]

Chromosome

 21

Cytoband

 q22.13

Chromosome location (bp)

 36750888 - 36990236

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159267 (version 83.38)

Entrez gene

 3141

UniProt

 P50747 (UniProt - Evidence at protein level)

neXtProt

 NX_P50747

Antibodypedia

 HLCS antibodies

PROTEIN BROWSER
HLCS-001
HLCS-002
HLCS-003
HLCS-004
HLCS-005
HLCS-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HLCS-001
ENSP00000338387
ENST00000336648
P50747 [Direct mapping]
Biotin--protein ligase Biotin--[methylmalonyl-CoA-carboxytransferase] ligase Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase Biotin--[methylcrotonoyl-CoA-carboxylase] ligase Biotin--[acetyl-CoA-carboxylase] ligase
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Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0004077 [biotin-[acetyl-CoA-carboxylase] ligase activity]
GO:0004078 [biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity]
GO:0004079 [biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity]
GO:0004080 [biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005652 [nuclear lamina]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0008283 [cell proliferation]
GO:0009305 [protein biotinylation]
GO:0009374 [biotin binding]
GO:0016363 [nuclear matrix]
GO:0016570 [histone modification]
GO:0018271 [biotin-protein ligase activity]
GO:0019899 [enzyme binding]
GO:0044281 [small molecule metabolic process]
GO:0070781 [response to biotin]
GO:0071110 [histone biotinylation]
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 726 aa
80.8 kDa 		No 0
HLCS-002
ENSP00000382071
ENST00000399120
P50747 [Direct mapping]
Biotin--protein ligase Biotin--[methylmalonyl-CoA-carboxytransferase] ligase Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase Biotin--[methylcrotonoyl-CoA-carboxylase] ligase Biotin--[acetyl-CoA-carboxylase] ligase
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0004077 [biotin-[acetyl-CoA-carboxylase] ligase activity]
GO:0004078 [biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity]
GO:0004079 [biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity]
GO:0004080 [biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005652 [nuclear lamina]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0008283 [cell proliferation]
GO:0009305 [protein biotinylation]
GO:0009374 [biotin binding]
GO:0016363 [nuclear matrix]
GO:0016570 [histone modification]
GO:0018271 [biotin-protein ligase activity]
GO:0019899 [enzyme binding]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0070781 [response to biotin]
GO:0071110 [histone biotinylation]
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 726 aa
80.8 kDa 		No 0
HLCS-003
ENSP00000392923
ENST00000448340
A0A0C4DG27 [Direct mapping]
Biotin--protein ligase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004077 [biotin-[acetyl-CoA-carboxylase] ligase activity]
GO:0006464 [cellular protein modification process]
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 92 aa
10.1 kDa 		No 0
HLCS-004
ENSP00000396443
ENST00000427746
C9JCQ9 [Direct mapping]
Biotin--protein ligase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004077 [biotin-[acetyl-CoA-carboxylase] ligase activity]
GO:0006464 [cellular protein modification process]
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 77 aa
8.8 kDa 		No 0
HLCS-005
ENSP00000396370
ENST00000419461
C9JD75 [Direct mapping]
Biotin--protein ligase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004077 [biotin-[acetyl-CoA-carboxylase] ligase activity]
GO:0006464 [cellular protein modification process]
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 87 aa
9.6 kDa 		No 0
HLCS-201
ENSP00000479939
ENST00000612277
P50747 [Direct mapping]
Biotin--protein ligase Biotin--[methylmalonyl-CoA-carboxytransferase] ligase Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase Biotin--[methylcrotonoyl-CoA-carboxylase] ligase Biotin--[acetyl-CoA-carboxylase] ligase
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0004077 [biotin-[acetyl-CoA-carboxylase] ligase activity]
GO:0004078 [biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity]
GO:0004079 [biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity]
GO:0004080 [biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005652 [nuclear lamina]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0008283 [cell proliferation]
GO:0009305 [protein biotinylation]
GO:0009374 [biotin binding]
GO:0016363 [nuclear matrix]
GO:0016570 [histone modification]
GO:0018271 [biotin-protein ligase activity]
GO:0019899 [enzyme binding]
GO:0044281 [small molecule metabolic process]
GO:0070781 [response to biotin]
GO:0071110 [histone biotinylation]
Show all
 726 aa
80.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.