Expression of GOLGA6A in cancer - Summary - The Human Protein Atlas

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GOLGA6A

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GOLGA6A
Gene description	Golgin A6 family, member A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (U-266/70)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in cells in seminiferous ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA044978 , HPA050087
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044978	HPA050087

GENE INFORMATION
Gene name	GOLGA6A (HGNC Symbol)
Synonyms	GLP, GOLGA6
Description	Golgin A6 family, member A (HGNC Symbol)
Entrez gene summary	The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The protein encoded by this gene is a member of the golgin family of proteins, whose members localize to the Golgi. This gene is found in a large, low copy repeat sequence or duplicon that is found in multiple copies, that are greather than 90% similar, on chromosome 15. Duplicons are associated with deletions, inversions and other chromosome rearrangements that underlie genomic disease. The protein encoded by this gene is thought to be a functional golgin protein while the majority of the related copies of this gene are thought to be transcribed pseudogenes. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q24.1
Chromosome location (bp)	74069857 - 74082550
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159289 (version 83.38)
Entrez gene	342096
UniProt	Q9NYA3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NYA3
Antibodypedia	GOLGA6A antibodies

PROTEIN BROWSER

GOLGA6A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GOLGA6A-001 ENSP00000290438 ENST00000290438	Q9NYA3 [Direct mapping] Golgin subfamily A member 6A Show all	Predicted intracellular proteins Show all	GO:0005794 [Golgi apparatus] Show all	693 aa 79.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.