Cell atlas - ARHGAP27 - The Human Protein Atlas

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ARHGAP27

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ARHGAP27
Gene description	Rho GTPase activating protein 27
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nucleus.
RNA cell category	Cell line enhanced (RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Nucleus (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA023919 , HPA053053
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nucleus.

Main location

Cytosol (supported)

Additional location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA023919	RT4	Nucleoplasm
HPA023919	U-2 OS	No staining
HPA023919	U-251 MG	Nucleoplasm
HPA023919	U-251 MG	Cytosol
HPA053053	RT4	Nucleoplasm
HPA053053	U-2 OS	Nucleus
HPA053053	U-2 OS	Cytosol
HPA053053	U-251 MG	Nucleus
HPA053053	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ARHGAP27 (HGNC Symbol)
Synonyms	CAMGAP1, FLJ43547, SH3D20, SH3P20
Description	Rho GTPase activating protein 27 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	45393902 - 45434421
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159314 (version 83.38)
Entrez gene	201176
UniProt	Q6ZUM4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZUM4
Antibodypedia	ARHGAP27 antibodies

PROTEIN BROWSER

ARHGAP27-001	ARHGAP27-003	ARHGAP27-004	ARHGAP27-006	ARHGAP27-009	ARHGAP27-011	ARHGAP27-201	ARHGAP27-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGAP27-001 ENSP00000366121 ENST00000376922	Q6ZUM4 [Direct mapping] Rho GTPase-activating protein 27 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006898 [receptor-mediated endocytosis] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0017124 [SH3 domain binding] GO:0043547 [positive regulation of GTPase activity] Show all	548 aa 61.7 kDa	No	0
ARHGAP27-003 ENSP00000432762 ENST00000532038	E9PNT2 [Direct mapping] Rho GTPase-activating protein 27 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	667 aa 75 kDa	No	0
ARHGAP27-004 ENSP00000437100 ENST00000528677	E9PNX6 [Direct mapping] Rho GTPase-activating protein 27 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	214 aa 23.4 kDa	No	0
ARHGAP27-006 ENSP00000431591 ENST00000528384	A0A0C4DGE6 [Direct mapping] Rho GTPase-activating protein 27 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0007165 [signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	521 aa 58.4 kDa	No	0
ARHGAP27-009 ENSP00000433942 ENST00000532891	E9PIR1 [Direct mapping] Rho GTPase-activating protein 27 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	867 aa 96.1 kDa	No	0
ARHGAP27-011 ENSP00000436137 ENST00000528273	Q6ZUM4 [Direct mapping] Rho GTPase-activating protein 27 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006898 [receptor-mediated endocytosis] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0017124 [SH3 domain binding] GO:0043547 [positive regulation of GTPase activity] Show all	263 aa 28.2 kDa	No	0
ARHGAP27-201 ENSP00000290470 ENST00000290470	Q6ZUM4 [Direct mapping] Rho GTPase-activating protein 27 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006898 [receptor-mediated endocytosis] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0017124 [SH3 domain binding] GO:0043547 [positive regulation of GTPase activity] Show all	263 aa 28.2 kDa	No	0
ARHGAP27-202 ENSP00000403323 ENST00000428638	Q6ZUM4 [Direct mapping] Rho GTPase-activating protein 27 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006898 [receptor-mediated endocytosis] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0017124 [SH3 domain binding] GO:0043547 [positive regulation of GTPase activity] Show all	889 aa 98.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.