Expression of CES5A in cancer - Summary - The Human Protein Atlas

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CES5A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CES5A
Gene description	Carboxylesterase 5A
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (liver cancer)
HPA (cell line):	Cell line enriched (U-266/70)
HPA (normal tissue):	Tissue enriched (epididymis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA047635
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047635

GENE INFORMATION
Gene name	CES5A (HGNC Symbol)
Synonyms	CAUXIN, CES4C1, CES5, CES7, FLJ31547
Description	Carboxylesterase 5A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Chromosome	16
Cytoband	q12.2
Chromosome location (bp)	55846154 - 55956031
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159398 (version 83.38)
Entrez gene	221223
UniProt	Q6NT32 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6NT32
Antibodypedia	CES5A antibodies

PROTEIN BROWSER

CES5A-001	CES5A-002	CES5A-004	CES5A-005	CES5A-006	CES5A-010	CES5A-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CES5A-001 ENSP00000324271 ENST00000319165	Q6NT32 [Direct mapping] Carboxylesterase 5A V9HWK3 [Target identity:100%; Query identity:100%] Carboxylic ester hydrolase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004771 [sterol esterase activity] GO:0004806 [triglyceride lipase activity] GO:0005615 [extracellular space] GO:0016042 [lipid catabolic process] Show all	525 aa 58.2 kDa	Yes	0
CES5A-002 ENSP00000290567 ENST00000290567	Q6NT32 [Direct mapping] Carboxylesterase 5A Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004771 [sterol esterase activity] GO:0004806 [triglyceride lipase activity] GO:0005615 [extracellular space] GO:0016042 [lipid catabolic process] Show all	575 aa 63.9 kDa	Yes	0
CES5A-004 ENSP00000428864 ENST00000521992	Q6NT32 [Direct mapping] Carboxylesterase 5A Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004771 [sterol esterase activity] GO:0004806 [triglyceride lipase activity] GO:0005615 [extracellular space] GO:0016042 [lipid catabolic process] Show all	604 aa 67.5 kDa	No	0
CES5A-005 ENSP00000428571 ENST00000518005	Q6NT32 [Direct mapping] Carboxylesterase 5A Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004771 [sterol esterase activity] GO:0004806 [triglyceride lipase activity] GO:0005615 [extracellular space] GO:0016042 [lipid catabolic process] Show all	469 aa 52.3 kDa	No	0
CES5A-006 ENSP00000428887 ENST00000520435	E5RFG9 [Direct mapping] Carboxylic ester hydrolase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	545 aa 60.6 kDa	Yes	0
CES5A-010 ENSP00000487767 ENST00000541580		MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		355 aa 40.3 kDa	No	0
CES5A-011 ENSP00000439810 ENST00000536025	F5H0J7 [Direct mapping] Carboxylesterase 5A Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		75 aa 8.1 kDa	No	0

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The Human Protein Atlas

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