Expression of C1R in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	C1R
Gene description	Complement component 1, r subcomponent
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, BJ hTERT+, BJ hTERT+ SV40 Large T+ RasG12V)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression and plasma positivity in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA001251 , HPA001551
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA001251	HPA001551

GENE INFORMATION
Gene name	C1R
Synonyms
Description	Complement component 1, r subcomponent (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	7080209 - 7092607
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159403 (version 83.38)
Entrez gene	715
UniProt	P00736 (UniProt - Evidence at protein level)
neXtProt	NX_P00736
Antibodypedia	C1R antibodies

PROTEIN BROWSER

C1R-001	C1R-003	C1R-004	C1R-006	C1R-007	C1R-009	C1R-011	C1R-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C1R-001 ENSP00000438615 ENST00000542285	P00736 [Direct mapping] Complement C1r subcomponent Complement C1r subcomponent heavy chain Complement C1r subcomponent light chain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006955 [immune response] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0008236 [serine-type peptidase activity] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	705 aa 80.2 kDa	Yes	0
C1R-003 ENSP00000438636 ENST00000535233	F5H2D0 [Direct mapping] Complement C1r subcomponent Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006956 [complement activation] Show all	671 aa 76.6 kDa	Yes	0
C1R-004 ENSP00000444271 ENST00000536053	B4DPQ0 [Direct mapping] Complement C1r subcomponent; cDNA FLJ54471, highly similar to Complement C1r subcomponent (EC 3.4.21.41) Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006956 [complement activation] Show all	719 aa 81.9 kDa	Yes	0
C1R-006 ENSP00000439223 ENST00000540610	F5H3A3 [Direct mapping] Complement C1r subcomponent Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	94 aa 10.8 kDa	No	0
C1R-007 ENSP00000441601 ENST00000541042	F5GWL0 [Direct mapping] Complement C1r subcomponent Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	72 aa 8.2 kDa	No	0
C1R-009 ENSP00000442946 ENST00000540242	F5H6Y3 [Direct mapping] Complement C1r subcomponent Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		156 aa 17.6 kDa	Yes	0
C1R-011 ENSP00000445285 ENST00000543835	F5H3N3 [Direct mapping] Complement C1r subcomponent Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	156 aa 17.9 kDa	Yes	0
C1R-013 ENSP00000444009 ENST00000538050	F5H1N6 [Direct mapping] Complement C1r subcomponent Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		49 aa 5.6 kDa	No	0