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CELF3

GENERAL INFORMATION

Gene name

 CELF3

Gene description

 CUGBP, Elav-like family member 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (adrenal gland, cerebral cortex)
GTEx:Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5:Tissue enhanced (caudate, cerebellum, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA006292
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, cerebellum, pituitary gland)

GENE INFORMATION

Gene name

 CELF3 (HGNC Symbol)

Synonyms

 BRUNOL1, CAGH4, ERDA4, MGC57297, TNRC4

Description

 CUGBP, Elav-like family member 3 (HGNC Symbol)

Entrez gene summary

 Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 151702404 - 151716814

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159409 (version 83.38)

Entrez gene

 11189

UniProt

 Q5SZQ8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5SZQ8

Antibodypedia

 CELF3 antibodies

PROTEIN BROWSER
CELF3-001
CELF3-002
CELF3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CELF3-001
ENSP00000290583
ENST00000290583
Q5SZQ8 [Direct mapping]
CUGBP Elav-like family member 3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007283 [spermatogenesis]
GO:0008380 [RNA splicing]
GO:0030317 [sperm motility]
GO:0048026 [positive regulation of mRNA splicing, via spliceosome]
Show all
 465 aa
50.5 kDa 		No 0
CELF3-002
ENSP00000290585
ENST00000290585
Q5SZQ8 [Direct mapping]
CUGBP Elav-like family member 3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0008380 [RNA splicing]
GO:0048026 [positive regulation of mRNA splicing, via spliceosome]
Show all
 415 aa
45.7 kDa 		No 0
CELF3-003
ENSP00000402503
ENST00000420342
H0Y623 [Direct mapping]
CUGBP Elav-like family member 3
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Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 466 aa
50.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.