Tissue expression of NAE1 - Summary - The Human Protein Atlas

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NAE1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	NAE1
Gene description	NEDD8 activating enzyme E1 subunit 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic and nuclear expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA041178 , HPA042041
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	NAE1 (HGNC Symbol)
Synonyms	APPBP1, ula-1
Description	NEDD8 activating enzyme E1 subunit 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	66802875 - 66873256
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159593 (version 83.38)
Entrez gene	8883
UniProt	Q13564 (UniProt - Evidence at protein level)
neXtProt	NX_Q13564
Antibodypedia	NAE1 antibodies

PROTEIN BROWSER

NAE1-001	NAE1-002	NAE1-004	NAE1-005	NAE1-010	NAE1-011	NAE1-014	NAE1-018	NAE1-020	NAE1-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAE1-001 ENSP00000290810 ENST00000290810	Q13564 [Direct mapping] NEDD8-activating enzyme E1 regulatory subunit Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0008641 [small protein activating enzyme activity] GO:0019781 [NEDD8 activating enzyme activity] GO:0031625 [ubiquitin protein ligase binding] GO:0033314 [mitotic DNA replication checkpoint] GO:0042981 [regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0045116 [protein neddylation] GO:0046982 [protein heterodimerization activity] GO:0051402 [neuron apoptotic process] Show all	534 aa 60.2 kDa	No	0
NAE1-002 ENSP00000351990 ENST00000359087	Q13564 [Direct mapping] NEDD8-activating enzyme E1 regulatory subunit Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0008641 [small protein activating enzyme activity] GO:0019781 [NEDD8 activating enzyme activity] GO:0031625 [ubiquitin protein ligase binding] GO:0033314 [mitotic DNA replication checkpoint] GO:0042981 [regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0045116 [protein neddylation] GO:0046982 [protein heterodimerization activity] GO:0051402 [neuron apoptotic process] Show all	537 aa 60.5 kDa	No	0
NAE1-004 ENSP00000377637 ENST00000394074	Q13564 [Direct mapping] NEDD8-activating enzyme E1 regulatory subunit Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0008641 [small protein activating enzyme activity] GO:0019781 [NEDD8 activating enzyme activity] GO:0031625 [ubiquitin protein ligase binding] GO:0033314 [mitotic DNA replication checkpoint] GO:0042981 [regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0045116 [protein neddylation] GO:0046982 [protein heterodimerization activity] GO:0051402 [neuron apoptotic process] Show all	445 aa 50.6 kDa	No	0
NAE1-005 ENSP00000368776 ENST00000379463	Q13564 [Direct mapping] NEDD8-activating enzyme E1 regulatory subunit Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0008641 [small protein activating enzyme activity] GO:0019781 [NEDD8 activating enzyme activity] GO:0031625 [ubiquitin protein ligase binding] GO:0033314 [mitotic DNA replication checkpoint] GO:0042981 [regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0045116 [protein neddylation] GO:0046982 [protein heterodimerization activity] GO:0051402 [neuron apoptotic process] Show all	528 aa 59.4 kDa	No	0
NAE1-010 ENSP00000464119 ENST00000561579	J3QRA5 [Direct mapping] NEDD8-activating enzyme E1 regulatory subunit Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008641 [small protein activating enzyme activity] Show all	124 aa 14.4 kDa	No	0
NAE1-011 ENSP00000462937 ENST00000566663	J3KTE3 [Direct mapping] NEDD8-activating enzyme E1 regulatory subunit Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008641 [small protein activating enzyme activity] Show all	129 aa 14.8 kDa	No	0
NAE1-014 ENSP00000454506 ENST00000563185	H3BMR3 [Direct mapping] NEDD8-activating enzyme E1 regulatory subunit Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008641 [small protein activating enzyme activity] Show all	109 aa 13 kDa	No	0
NAE1-018 ENSP00000463546 ENST00000562428	J3QLH4 [Direct mapping] NEDD8-activating enzyme E1 regulatory subunit Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008641 [small protein activating enzyme activity] Show all	112 aa 12.5 kDa	No	0
NAE1-020 ENSP00000462040 ENST00000566336	J3KRK3 [Direct mapping] NEDD8-activating enzyme E1 regulatory subunit Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008641 [small protein activating enzyme activity] Show all	162 aa 17.8 kDa	No	0
NAE1-021 ENSP00000455967 ENST00000565535	H3BQW6 [Direct mapping] NEDD8-activating enzyme E1 regulatory subunit Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008641 [small protein activating enzyme activity] Show all	167 aa 18.2 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.