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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ACE

Gene description

Angiotensin I converting enzyme

Protein class

Candidate cardiovascular disease genes
CD markers
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1, HUVEC TERT2)
HPA (normal tissue):Tissue enhanced (duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in selected tissues, including lung capillaries, small intestine, renal tubules, uterus and male genitalia.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA029298 , CAB002426 , CAB002921
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA029298
CAB002426
CAB002921

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues in general were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Melanoma, glioma, skin and urothelial cancers as well as a majority of cases of most other cancers were weakly stained or negative. A few cases of most cancers showed moderate to strong luminal membranous positivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of cancer showed strong cytoplasmic positivity, e.g. lymphomas, testis, lung, breast, prostate, endometrial and renal carcinomas. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

ACE (HGNC Symbol)

Synonyms

ACE1, CD143, DCP1

Description

Angiotensin I converting enzyme (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]

Chromosome

17

Cytoband

q23.3

Chromosome location (bp)

63477061 - 63498380

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159640 (version 83.38)

Entrez gene

1636

UniProt

P12821 (UniProt - Evidence at protein level)

neXtProt

NX_P12821

Antibodypedia

ACE antibodies

PROTEIN BROWSER

ACE-001
ACE-007
ACE-009
ACE-011
ACE-017
ACE-020
ACE-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACE-001
ENSP00000290866
ENST00000290866
P12821 [Direct mapping]
Angiotensin-converting enzyme Angiotensin-converting enzyme, soluble form
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0001974 [blood vessel remodeling]
GO:0002003 [angiotensin maturation]
GO:0002005 [angiotensin catabolic process in blood]
GO:0002019 [regulation of renal output by angiotensin]
GO:0002446 [neutrophil mediated immunity]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin]
GO:0003779 [actin binding]
GO:0004175 [endopeptidase activity]
GO:0004180 [carboxypeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007283 [spermatogenesis]
GO:0008144 [drug binding]
GO:0008217 [regulation of blood pressure]
GO:0008237 [metallopeptidase activity]
GO:0008238 [exopeptidase activity]
GO:0008240 [tripeptidyl-peptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009897 [external side of plasma membrane]
GO:0014910 [regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0031404 [chloride ion binding]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031711 [bradykinin receptor binding]
GO:0032943 [mononuclear cell proliferation]
GO:0042312 [regulation of vasodilation]
GO:0042447 [hormone catabolic process]
GO:0043171 [peptide catabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0050435 [beta-amyloid metabolic process]
GO:0050482 [arachidonic acid secretion]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0060047 [heart contraction]
GO:0060177 [regulation of angiotensin metabolic process]
GO:0060218 [hematopoietic stem cell differentiation]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070062 [extracellular exosome]
GO:0071838 [cell proliferation in bone marrow]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1902033 [regulation of hematopoietic stem cell proliferation]
GO:1903597 [negative regulation of gap junction assembly]
GO:2000170 [positive regulation of peptidyl-cysteine S-nitrosylation]
Show all
1306 aa
149.7 kDa
Yes 1
ACE-007
ENSP00000290863
ENST00000290863
P12821 [Direct mapping]
Angiotensin-converting enzyme Angiotensin-converting enzyme, soluble form
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0001974 [blood vessel remodeling]
GO:0002003 [angiotensin maturation]
GO:0002005 [angiotensin catabolic process in blood]
GO:0002019 [regulation of renal output by angiotensin]
GO:0002446 [neutrophil mediated immunity]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin]
GO:0003779 [actin binding]
GO:0004175 [endopeptidase activity]
GO:0004180 [carboxypeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007283 [spermatogenesis]
GO:0008144 [drug binding]
GO:0008217 [regulation of blood pressure]
GO:0008237 [metallopeptidase activity]
GO:0008238 [exopeptidase activity]
GO:0008240 [tripeptidyl-peptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009897 [external side of plasma membrane]
GO:0014910 [regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0031404 [chloride ion binding]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031711 [bradykinin receptor binding]
GO:0032943 [mononuclear cell proliferation]
GO:0042312 [regulation of vasodilation]
GO:0042447 [hormone catabolic process]
GO:0043171 [peptide catabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0050435 [beta-amyloid metabolic process]
GO:0050482 [arachidonic acid secretion]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0060047 [heart contraction]
GO:0060177 [regulation of angiotensin metabolic process]
GO:0060218 [hematopoietic stem cell differentiation]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070062 [extracellular exosome]
GO:0071838 [cell proliferation in bone marrow]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1902033 [regulation of hematopoietic stem cell proliferation]
GO:1903597 [negative regulation of gap junction assembly]
GO:2000170 [positive regulation of peptidyl-cysteine S-nitrosylation]
Show all
732 aa
83.3 kDa
Yes 1
ACE-009
ENSP00000392247
ENST00000413513
P12821 [Direct mapping]
Angiotensin-converting enzyme Angiotensin-converting enzyme, soluble form
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0001974 [blood vessel remodeling]
GO:0002003 [angiotensin maturation]
GO:0002005 [angiotensin catabolic process in blood]
GO:0002019 [regulation of renal output by angiotensin]
GO:0002446 [neutrophil mediated immunity]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin]
GO:0003779 [actin binding]
GO:0004175 [endopeptidase activity]
GO:0004180 [carboxypeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007283 [spermatogenesis]
GO:0008144 [drug binding]
GO:0008217 [regulation of blood pressure]
GO:0008237 [metallopeptidase activity]
GO:0008238 [exopeptidase activity]
GO:0008240 [tripeptidyl-peptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009897 [external side of plasma membrane]
GO:0014910 [regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0031404 [chloride ion binding]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031711 [bradykinin receptor binding]
GO:0032943 [mononuclear cell proliferation]
GO:0042312 [regulation of vasodilation]
GO:0042447 [hormone catabolic process]
GO:0043171 [peptide catabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0050435 [beta-amyloid metabolic process]
GO:0050482 [arachidonic acid secretion]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0060047 [heart contraction]
GO:0060177 [regulation of angiotensin metabolic process]
GO:0060218 [hematopoietic stem cell differentiation]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070062 [extracellular exosome]
GO:0071838 [cell proliferation in bone marrow]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1902033 [regulation of hematopoietic stem cell proliferation]
GO:1903597 [negative regulation of gap junction assembly]
GO:2000170 [positive regulation of peptidyl-cysteine S-nitrosylation]
Show all
691 aa
78.7 kDa
Yes 1
ACE-011
ENSP00000462280
ENST00000582627
J3KS28 [Direct mapping]
Angiotensin-converting enzyme
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0016020 [membrane]
GO:0046872 [metal ion binding]
Show all
314 aa
35.5 kDa
No 0
ACE-017
ENSP00000462909
ENST00000582761
J3KTB8 [Direct mapping]
Angiotensin-converting enzyme
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0016020 [membrane]
GO:0046872 [metal ion binding]
Show all
282 aa
33 kDa
No 0
ACE-020
ENSP00000464428
ENST00000579409
J3QRX8 [Direct mapping]
Angiotensin-converting enzyme
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0016020 [membrane]
Show all
138 aa
15.4 kDa
No 0
ACE-201
ENSP00000397593
ENST00000428043
A0A0A0MSN4 [Direct mapping]
Angiotensin-converting enzyme
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0016020 [membrane]
GO:0046872 [metal ion binding]
Show all
1242 aa
142.4 kDa
Yes 0

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