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ACE

GENERAL INFORMATION

Gene name

 ACE

Gene description

 Angiotensin I converting enzyme

Protein class

 Candidate cardiovascular disease genes
CD markers
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1, HUVEC TERT2)
HPA (normal tissue):Tissue enhanced (duodenum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in selected tissues, including lung capillaries, small intestine, renal tubules, uterus and male genitalia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA029298 , CAB002426 , CAB002921
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029298
CAB002426
CAB002921

GENE INFORMATION

Gene name

 ACE (HGNC Symbol)

Synonyms

 ACE1, CD143, DCP1

Description

 Angiotensin I converting enzyme (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]

Chromosome

 17

Cytoband

 q23.3

Chromosome location (bp)

 63477061 - 63498380

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159640 (version 83.38)

Entrez gene

 1636

UniProt

 P12821 (UniProt - Evidence at protein level)

neXtProt

 NX_P12821

Antibodypedia

 ACE antibodies

PROTEIN BROWSER
ACE-001
ACE-007
ACE-009
ACE-011
ACE-017
ACE-020
ACE-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACE-001
ENSP00000290866
ENST00000290866
P12821 [Direct mapping]
Angiotensin-converting enzyme Angiotensin-converting enzyme, soluble form
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0001974 [blood vessel remodeling]
GO:0002003 [angiotensin maturation]
GO:0002005 [angiotensin catabolic process in blood]
GO:0002019 [regulation of renal output by angiotensin]
GO:0002446 [neutrophil mediated immunity]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin]
GO:0003779 [actin binding]
GO:0004175 [endopeptidase activity]
GO:0004180 [carboxypeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007283 [spermatogenesis]
GO:0008144 [drug binding]
GO:0008217 [regulation of blood pressure]
GO:0008237 [metallopeptidase activity]
GO:0008238 [exopeptidase activity]
GO:0008240 [tripeptidyl-peptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009897 [external side of plasma membrane]
GO:0014910 [regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0031404 [chloride ion binding]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031711 [bradykinin receptor binding]
GO:0032943 [mononuclear cell proliferation]
GO:0042312 [regulation of vasodilation]
GO:0042447 [hormone catabolic process]
GO:0043171 [peptide catabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0050435 [beta-amyloid metabolic process]
GO:0050482 [arachidonic acid secretion]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0060047 [heart contraction]
GO:0060177 [regulation of angiotensin metabolic process]
GO:0060218 [hematopoietic stem cell differentiation]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070062 [extracellular exosome]
GO:0071838 [cell proliferation in bone marrow]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1902033 [regulation of hematopoietic stem cell proliferation]
GO:1903597 [negative regulation of gap junction assembly]
GO:2000170 [positive regulation of peptidyl-cysteine S-nitrosylation]
Show all
 1306 aa
149.7 kDa 		Yes 1
ACE-007
ENSP00000290863
ENST00000290863
P12821 [Direct mapping]
Angiotensin-converting enzyme Angiotensin-converting enzyme, soluble form
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0001974 [blood vessel remodeling]
GO:0002003 [angiotensin maturation]
GO:0002005 [angiotensin catabolic process in blood]
GO:0002019 [regulation of renal output by angiotensin]
GO:0002446 [neutrophil mediated immunity]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin]
GO:0003779 [actin binding]
GO:0004175 [endopeptidase activity]
GO:0004180 [carboxypeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007283 [spermatogenesis]
GO:0008144 [drug binding]
GO:0008217 [regulation of blood pressure]
GO:0008237 [metallopeptidase activity]
GO:0008238 [exopeptidase activity]
GO:0008240 [tripeptidyl-peptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009897 [external side of plasma membrane]
GO:0014910 [regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0031404 [chloride ion binding]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031711 [bradykinin receptor binding]
GO:0032943 [mononuclear cell proliferation]
GO:0042312 [regulation of vasodilation]
GO:0042447 [hormone catabolic process]
GO:0043171 [peptide catabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0050435 [beta-amyloid metabolic process]
GO:0050482 [arachidonic acid secretion]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0060047 [heart contraction]
GO:0060177 [regulation of angiotensin metabolic process]
GO:0060218 [hematopoietic stem cell differentiation]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070062 [extracellular exosome]
GO:0071838 [cell proliferation in bone marrow]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1902033 [regulation of hematopoietic stem cell proliferation]
GO:1903597 [negative regulation of gap junction assembly]
GO:2000170 [positive regulation of peptidyl-cysteine S-nitrosylation]
Show all
 732 aa
83.3 kDa 		Yes 1
ACE-009
ENSP00000392247
ENST00000413513
P12821 [Direct mapping]
Angiotensin-converting enzyme Angiotensin-converting enzyme, soluble form
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0001974 [blood vessel remodeling]
GO:0002003 [angiotensin maturation]
GO:0002005 [angiotensin catabolic process in blood]
GO:0002019 [regulation of renal output by angiotensin]
GO:0002446 [neutrophil mediated immunity]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin]
GO:0003779 [actin binding]
GO:0004175 [endopeptidase activity]
GO:0004180 [carboxypeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007283 [spermatogenesis]
GO:0008144 [drug binding]
GO:0008217 [regulation of blood pressure]
GO:0008237 [metallopeptidase activity]
GO:0008238 [exopeptidase activity]
GO:0008240 [tripeptidyl-peptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009897 [external side of plasma membrane]
GO:0014910 [regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0031404 [chloride ion binding]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031711 [bradykinin receptor binding]
GO:0032943 [mononuclear cell proliferation]
GO:0042312 [regulation of vasodilation]
GO:0042447 [hormone catabolic process]
GO:0043171 [peptide catabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0050435 [beta-amyloid metabolic process]
GO:0050482 [arachidonic acid secretion]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0060047 [heart contraction]
GO:0060177 [regulation of angiotensin metabolic process]
GO:0060218 [hematopoietic stem cell differentiation]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070062 [extracellular exosome]
GO:0071838 [cell proliferation in bone marrow]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1902033 [regulation of hematopoietic stem cell proliferation]
GO:1903597 [negative regulation of gap junction assembly]
GO:2000170 [positive regulation of peptidyl-cysteine S-nitrosylation]
Show all
 691 aa
78.7 kDa 		Yes 1
ACE-011
ENSP00000462280
ENST00000582627
J3KS28 [Direct mapping]
Angiotensin-converting enzyme
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0016020 [membrane]
GO:0046872 [metal ion binding]
Show all
 314 aa
35.5 kDa 		No 0
ACE-017
ENSP00000462909
ENST00000582761
J3KTB8 [Direct mapping]
Angiotensin-converting enzyme
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0016020 [membrane]
GO:0046872 [metal ion binding]
Show all
 282 aa
33 kDa 		No 0
ACE-020
ENSP00000464428
ENST00000579409
J3QRX8 [Direct mapping]
Angiotensin-converting enzyme
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0016020 [membrane]
Show all
 138 aa
15.4 kDa 		No 0
ACE-201
ENSP00000397593
ENST00000428043
A0A0A0MSN4 [Direct mapping]
Angiotensin-converting enzyme
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0016020 [membrane]
GO:0046872 [metal ion binding]
Show all
 1242 aa
142.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.