Expression of ACE in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene nameⁱ Gene name according to HGNC.	ACE
Gene descriptionⁱ Gene description according to HGNC.	Angiotensin I converting enzyme
Protein classⁱ Protein class the gene product belongs to according to selected gene lists. List of protein classes.	Candidate cardiovascular disease genes CD markers Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localizationⁱ Protein localization predicted from several bioinformatic algorithms. Read more	Intracellular,Membrane,Secreted
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryⁱ

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, HUVEC TERT2)
HPA (normal tissue):	Tissue enhanced (duodenum, small intestine)

Protein evidenceⁱ

Evidence at protein level

Protein expression
normal tissueⁱ

Cytoplasmic and membranous expression in selected tissues, including lung capillaries, small intestine, renal tubules, uterus and male genitalia.

ANTIBODY IHC RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.	Antibody staining consistent with RNA expression data.
Reliability scoreⁱ Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data. Read more	Supported based on 3 antibodies. HPA029298 , CAB002426 , CAB002921
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PROGNOSTIC SUMMARYⁱ Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEWⁱ

TCGA datasetⁱ
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more

RNA cancer category: Expressed in all

PROTEIN EXPRESSIONⁱ

STAINING SUMMARYⁱ

HPA029298	CAB002426	CAB002921

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	ACE (HGNC Symbol)
Synonyms	ACE1, CD143, DCP1
Description	Angiotensin I converting enzyme (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
Chromosome	17
Cytoband	q23.3
Chromosome location (bp)	63477061 - 63498380
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159640 (version 83.38)
Entrez gene	1636
UniProt	P12821 (UniProt - Evidence at protein level)
neXtProt	NX_P12821
Antibodypedia	ACE antibodies

PROTEIN BROWSERⁱ

ACE-001	ACE-007	ACE-009	ACE-011	ACE-017	ACE-020	ACE-201

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACE-001 ENSP00000290866 ENST00000290866	P12821 [Direct mapping] Angiotensin-converting enzyme Angiotensin-converting enzyme, soluble form Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0001974 [blood vessel remodeling] GO:0002003 [angiotensin maturation] GO:0002005 [angiotensin catabolic process in blood] GO:0002019 [regulation of renal output by angiotensin] GO:0002446 [neutrophil mediated immunity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0003779 [actin binding] GO:0004175 [endopeptidase activity] GO:0004180 [carboxypeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007283 [spermatogenesis] GO:0008144 [drug binding] GO:0008217 [regulation of blood pressure] GO:0008237 [metallopeptidase activity] GO:0008238 [exopeptidase activity] GO:0008240 [tripeptidyl-peptidase activity] GO:0008241 [peptidyl-dipeptidase activity] GO:0008270 [zinc ion binding] GO:0009897 [external side of plasma membrane] GO:0014910 [regulation of smooth muscle cell migration] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0031404 [chloride ion binding] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0031711 [bradykinin receptor binding] GO:0032943 [mononuclear cell proliferation] GO:0042312 [regulation of vasodilation] GO:0042447 [hormone catabolic process] GO:0043171 [peptide catabolic process] GO:0044267 [cellular protein metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0050482 [arachidonic acid secretion] GO:0051019 [mitogen-activated protein kinase binding] GO:0060047 [heart contraction] GO:0060177 [regulation of angiotensin metabolic process] GO:0060218 [hematopoietic stem cell differentiation] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070062 [extracellular exosome] GO:0071838 [cell proliferation in bone marrow] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1902033 [regulation of hematopoietic stem cell proliferation] GO:1903597 [negative regulation of gap junction assembly] GO:2000170 [positive regulation of peptidyl-cysteine S-nitrosylation] Show all	1306 aa 149.7 kDa	Yes	1
ACE-007 ENSP00000290863 ENST00000290863	P12821 [Direct mapping] Angiotensin-converting enzyme Angiotensin-converting enzyme, soluble form Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0001974 [blood vessel remodeling] GO:0002003 [angiotensin maturation] GO:0002005 [angiotensin catabolic process in blood] GO:0002019 [regulation of renal output by angiotensin] GO:0002446 [neutrophil mediated immunity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0003779 [actin binding] GO:0004175 [endopeptidase activity] GO:0004180 [carboxypeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007283 [spermatogenesis] GO:0008144 [drug binding] GO:0008217 [regulation of blood pressure] GO:0008237 [metallopeptidase activity] GO:0008238 [exopeptidase activity] GO:0008240 [tripeptidyl-peptidase activity] GO:0008241 [peptidyl-dipeptidase activity] GO:0008270 [zinc ion binding] GO:0009897 [external side of plasma membrane] GO:0014910 [regulation of smooth muscle cell migration] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0031404 [chloride ion binding] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0031711 [bradykinin receptor binding] GO:0032943 [mononuclear cell proliferation] GO:0042312 [regulation of vasodilation] GO:0042447 [hormone catabolic process] GO:0043171 [peptide catabolic process] GO:0044267 [cellular protein metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0050482 [arachidonic acid secretion] GO:0051019 [mitogen-activated protein kinase binding] GO:0060047 [heart contraction] GO:0060177 [regulation of angiotensin metabolic process] GO:0060218 [hematopoietic stem cell differentiation] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070062 [extracellular exosome] GO:0071838 [cell proliferation in bone marrow] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1902033 [regulation of hematopoietic stem cell proliferation] GO:1903597 [negative regulation of gap junction assembly] GO:2000170 [positive regulation of peptidyl-cysteine S-nitrosylation] Show all	732 aa 83.3 kDa	Yes	1
ACE-009 ENSP00000392247 ENST00000413513	P12821 [Direct mapping] Angiotensin-converting enzyme Angiotensin-converting enzyme, soluble form Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0001974 [blood vessel remodeling] GO:0002003 [angiotensin maturation] GO:0002005 [angiotensin catabolic process in blood] GO:0002019 [regulation of renal output by angiotensin] GO:0002446 [neutrophil mediated immunity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0003779 [actin binding] GO:0004175 [endopeptidase activity] GO:0004180 [carboxypeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007283 [spermatogenesis] GO:0008144 [drug binding] GO:0008217 [regulation of blood pressure] GO:0008237 [metallopeptidase activity] GO:0008238 [exopeptidase activity] GO:0008240 [tripeptidyl-peptidase activity] GO:0008241 [peptidyl-dipeptidase activity] GO:0008270 [zinc ion binding] GO:0009897 [external side of plasma membrane] GO:0014910 [regulation of smooth muscle cell migration] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0031404 [chloride ion binding] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0031711 [bradykinin receptor binding] GO:0032943 [mononuclear cell proliferation] GO:0042312 [regulation of vasodilation] GO:0042447 [hormone catabolic process] GO:0043171 [peptide catabolic process] GO:0044267 [cellular protein metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0050482 [arachidonic acid secretion] GO:0051019 [mitogen-activated protein kinase binding] GO:0060047 [heart contraction] GO:0060177 [regulation of angiotensin metabolic process] GO:0060218 [hematopoietic stem cell differentiation] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070062 [extracellular exosome] GO:0071838 [cell proliferation in bone marrow] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1902033 [regulation of hematopoietic stem cell proliferation] GO:1903597 [negative regulation of gap junction assembly] GO:2000170 [positive regulation of peptidyl-cysteine S-nitrosylation] Show all	691 aa 78.7 kDa	Yes	1
ACE-011 ENSP00000462280 ENST00000582627	J3KS28 [Direct mapping] Angiotensin-converting enzyme Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008241 [peptidyl-dipeptidase activity] GO:0016020 [membrane] GO:0046872 [metal ion binding] Show all	314 aa 35.5 kDa	No	0
ACE-017 ENSP00000462909 ENST00000582761	J3KTB8 [Direct mapping] Angiotensin-converting enzyme Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008241 [peptidyl-dipeptidase activity] GO:0016020 [membrane] GO:0046872 [metal ion binding] Show all	282 aa 33 kDa	No	0
ACE-020 ENSP00000464428 ENST00000579409	J3QRX8 [Direct mapping] Angiotensin-converting enzyme Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008241 [peptidyl-dipeptidase activity] GO:0016020 [membrane] Show all	138 aa 15.4 kDa	No	0
ACE-201 ENSP00000397593 ENST00000428043	A0A0A0MSN4 [Direct mapping] Angiotensin-converting enzyme Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008241 [peptidyl-dipeptidase activity] GO:0016020 [membrane] GO:0046872 [metal ion binding] Show all	1242 aa 142.4 kDa	Yes	0