Expression of CHCHD6 in cancer - Summary - The Human Protein Atlas

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CHCHD6

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CHCHD6
Gene description	Coiled-coil-helix-coiled-coil-helix domain containing 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA047673
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047673

GENE INFORMATION
Gene name	CHCHD6 (HGNC Symbol)
Synonyms	CHCM1, MGC13016, Mic25, PPP1R23
Description	Coiled-coil-helix-coiled-coil-helix domain containing 6 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q21.3
Chromosome location (bp)	126704220 - 126960406
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159685 (version 83.38)
Entrez gene	84303
UniProt	Q9BRQ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BRQ6
Antibodypedia	CHCHD6 antibodies

PROTEIN BROWSER

CHCHD6-001	CHCHD6-002	CHCHD6-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHCHD6-001 ENSP00000290913 ENST00000290913	Q9BRQ6 [Direct mapping] MICOS complex subunit MIC25 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006974 [cellular response to DNA damage stimulus] GO:0042407 [cristae formation] GO:0061617 [MICOS complex] Show all	235 aa 26.5 kDa	No	0
CHCHD6-002 ENSP00000422912 ENST00000508789	J3QTA6 [Direct mapping] MICOS complex subunit MIC25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		256 aa 28.8 kDa	No	0
CHCHD6-008 ENSP00000422787 ENST00000513253	H0Y922 [Direct mapping] MICOS complex subunit MIC25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		166 aa 18.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.