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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PIP
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PIP

Gene description

Prolactin-induced protein

Protein class

Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (breast cancer)
HPA (cell line):Cell line enriched (T-47d)
HPA (normal tissue):Group enriched (breast, salivary gland, seminal vesicle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in salivary glandular cells and breast glands.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA009177 , CAB002661
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (breast cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA009177
CAB002661

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic immunoreactivity was observed in a few breast, ovarian, cervical and lung cancers. Most other tumors were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Breast cancers showed strong cytoplasmic positivity. Remaining cancers were negative.

GENE INFORMATION

Gene name

PIP (HGNC Symbol)

Synonyms

GCDFP-15, GCDFP15, GPIP4

Description

Prolactin-induced protein (HGNC Symbol)

Entrez gene summary

Chromosome

7

Cytoband

q34

Chromosome location (bp)

143132077 - 143139746

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159763 (version 83.38)

Entrez gene

5304

UniProt

P12273 (UniProt - Evidence at protein level)

neXtProt

NX_P12273

Antibodypedia

PIP antibodies

PROTEIN BROWSER

PIP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PIP-001
ENSP00000291009
ENST00000291009
P12273 [Direct mapping]
Prolactin-inducible protein
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste]
GO:0001895 [retina homeostasis]
GO:0001948 [glycoprotein binding]
GO:0002682 [regulation of immune system process]
GO:0003779 [actin binding]
GO:0004190 [aspartic-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0006508 [proteolysis]
GO:0010628 [positive regulation of gene expression]
GO:0016324 [apical plasma membrane]
GO:0019864 [IgG binding]
GO:0046983 [protein dimerization activity]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070233 [negative regulation of T cell apoptotic process]
Show all
146 aa
16.6 kDa
Yes 0

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