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ABR

GENERAL INFORMATION

Gene name

 ABR

Gene description

 Active BCR-related

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Daudi, TIME, U-251 MG)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA054824
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054824

GENE INFORMATION

Gene name

 ABR (HGNC Symbol)

Synonyms

 MDB

Description

 Active BCR-related (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 1003518 - 1229021

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159842 (version 83.38)

Entrez gene

 29

UniProt

 Q12979 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q12979

Antibodypedia

 ABR antibodies

PROTEIN BROWSER
«
ABR-001
ABR-002
ABR-003
ABR-004
ABR-005
ABR-013
ABR-014
ABR-024
ABR-025
ABR-026
ABR-029
ABR-030
ABR-031
ABR-032
ABR-034
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABR-001
ENSP00000303909
ENST00000302538
Q12979 [Direct mapping]
Active breakpoint cluster region-related protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002692 [negative regulation of cellular extravasation]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007420 [brain development]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0032496 [response to lipopolysaccharide]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042472 [inner ear morphogenesis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043314 [negative regulation of neutrophil degranulation]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0050766 [positive regulation of phagocytosis]
GO:0050885 [neuromuscular process controlling balance]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0060313 [negative regulation of blood vessel remodeling]
GO:0097190 [apoptotic signaling pathway]
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 859 aa
97.6 kDa 		No 0
ABR-002
ENSP00000461565
ENST00000574437
Q12979 [Direct mapping]
Active breakpoint cluster region-related protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
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 813 aa
92.4 kDa 		No 0
ABR-003
ENSP00000291107
ENST00000291107
Q12979 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
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 822 aa
93.7 kDa 		No 0
ABR-004
ENSP00000442048
ENST00000544583
Q12979 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
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 813 aa
92.4 kDa 		No 0
ABR-005
ENSP00000445198
ENST00000543210
Q12979 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
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 310 aa
35.1 kDa 		No 0
ABR-013
ENSP00000461795
ENST00000571797
I3NI05 [Direct mapping]
Active breakpoint cluster region-related protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0007165 [signal transduction]
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 191 aa
20.8 kDa 		No 0
ABR-014
ENSP00000459553
ENST00000572441
I3L2C0 [Direct mapping]
Active breakpoint cluster region-related protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0007165 [signal transduction]
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 153 aa
17.4 kDa 		No 0
ABR-024
ENSP00000458294
ENST00000574544
I3L0R7 [Direct mapping]
Active breakpoint cluster region-related protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 189 aa
21.8 kDa 		No 0
ABR-025
ENSP00000459118
ENST00000571945
I3L1U8 [Direct mapping]
Active breakpoint cluster region-related protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 165 aa
18.9 kDa 		No 0
ABR-026
ENSP00000437429
ENST00000536794
B7Z683 [Direct mapping]
Active breakpoint cluster region-related protein; cDNA FLJ54747, highly similar to Active breakpoint cluster region-related protein
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 641 aa
73.5 kDa 		No 0
ABR-029
ENSP00000460770
ENST00000575934
I3L3W0 [Direct mapping]
Active breakpoint cluster region-related protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 133 aa
14.8 kDa 		No 0
ABR-030
ENSP00000459820
ENST00000570441
I3L2P5 [Direct mapping]
Active breakpoint cluster region-related protein
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 168 aa
19.3 kDa 		No 0
ABR-031
ENSP00000459761
ENST00000570525
I3L2L3 [Direct mapping]
Active breakpoint cluster region-related protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 88 aa
9.2 kDa 		No 0
ABR-032
ENSP00000459406
ENST00000574266
I3L259 [Direct mapping]
Active breakpoint cluster region-related protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 86 aa
9 kDa 		No 0
ABR-034
ENSP00000461629
ENST00000574139
I3L4Y1 [Direct mapping]
Active breakpoint cluster region-related protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 129 aa
14.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.