Expression of LYPD5 in cancer - Summary - The Human Protein Atlas

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LYPD5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LYPD5
Gene description	LY6/PLAUR domain containing 5
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enhanced (A-431, BEWO, HaCaT)
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Weak cytoplasmic expression, most abundant in glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA042511 , HPA054670
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042511	HPA054670

GENE INFORMATION
Gene name	LYPD5 (HGNC Symbol)
Synonyms	FLJ30469
Description	LY6/PLAUR domain containing 5 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.31
Chromosome location (bp)	43795929 - 43827206
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159871 (version 83.38)
Entrez gene	284348
UniProt	Q6UWN5 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UWN5
Antibodypedia	LYPD5 antibodies

PROTEIN BROWSER

LYPD5-001	LYPD5-002	LYPD5-005	LYPD5-007	LYPD5-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LYPD5-001 ENSP00000367185 ENST00000377950	Q6UWN5 [Direct mapping] Ly6/PLAUR domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0031225 [anchored component of membrane] GO:0043236 [laminin binding] Show all	251 aa 26.9 kDa	Yes	1
LYPD5-002 ENSP00000471692 ENST00000594013	Q6UWN5 [Direct mapping] Ly6/PLAUR domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0031225 [anchored component of membrane] GO:0043236 [laminin binding] Show all	208 aa 22.2 kDa	No	1
LYPD5-005 ENSP00000408433 ENST00000414615	Q6UWN5 [Direct mapping] Ly6/PLAUR domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0031225 [anchored component of membrane] GO:0043236 [laminin binding] Show all	208 aa 22.2 kDa	No	1
LYPD5-007 ENSP00000471909 ENST00000602179	M0R1J4 [Direct mapping] Ly6/PLAUR domain-containing protein 5 Show all	Predicted intracellular proteins Show all		113 aa 12.1 kDa	No	0
LYPD5-008 ENSP00000470163 ENST00000594049	M0QYY3 [Direct mapping] Ly6/PLAUR domain-containing protein 5 Show all	Predicted intracellular proteins Show all		128 aa 13.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.