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TNFRSF13C

GENERAL INFORMATION

Gene name

 TNFRSF13C

Gene description

 Tumor necrosis factor receptor superfamily, member 13C

Protein class

 CD markers
Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (REH, U-698)
HPA (normal tissue):Group enriched (appendix, lymph node, spleen, tonsil)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in subsets of lymphoid cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA003246 , CAB008380
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003246
CAB008380

GENE INFORMATION

Gene name

 TNFRSF13C (HGNC Symbol)

Synonyms

 BAFFR, CD268

Description

 Tumor necrosis factor receptor superfamily, member 13C (HGNC Symbol)

Entrez gene summary

 B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q13.2

Chromosome location (bp)

 41922023 - 41926818

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159958 (version 83.38)

Entrez gene

 115650

UniProt

 Q96RJ3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96RJ3

Antibodypedia

 TNFRSF13C antibodies

PROTEIN BROWSER
TNFRSF13C-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNFRSF13C-001
ENSP00000291232
ENST00000291232
Q96RJ3 [Direct mapping]
Tumor necrosis factor receptor superfamily member 13C
Q5H8V1 [Target identity:100%; Query identity:100%]
BAFF receptor; BAFF-R; Tumor necrosis factor receptor superfamily, member 13C
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
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GO:0001782 [B cell homeostasis]
GO:0002250 [adaptive immune response]
GO:0002636 [positive regulation of germinal center formation]
GO:0005886 [plasma membrane]
GO:0009897 [external side of plasma membrane]
GO:0016021 [integral component of membrane]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031295 [T cell costimulation]
GO:0031296 [B cell costimulation]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0045078 [positive regulation of interferon-gamma biosynthetic process]
GO:0050776 [regulation of immune response]
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 184 aa
18.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.