Expression of PTGIR in cancer - Summary - The Human Protein Atlas

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PTGIR

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	PTGIR
Gene description	Prostaglandin I2 (prostacyclin) receptor (IP)
Protein class	FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BJ, BJ hTERT+, HDLM-2, HEL)
HPA (normal tissue):	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and testis cancer (unfavourable).
Renal cancer p<0.001 Testis cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	PTGIR (HGNC Symbol)
Synonyms	IP
Description	Prostaglandin I2 (prostacyclin) receptor (IP) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	46620468 - 46625118
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160013 (version 83.38)
Entrez gene	5739
UniProt	P43119 (UniProt - Evidence at protein level)
neXtProt	NX_P43119
Antibodypedia	PTGIR antibodies

PROTEIN BROWSER

PTGIR-001	PTGIR-002	PTGIR-004	PTGIR-005	PTGIR-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTGIR-001 ENSP00000291294 ENST00000291294	P43119 [Direct mapping] Prostacyclin receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0032496 [response to lipopolysaccharide] GO:0043547 [positive regulation of GTPase activity] GO:0043950 [positive regulation of cAMP-mediated signaling] GO:0048662 [negative regulation of smooth muscle cell proliferation] Show all	386 aa 41 kDa	No	7
PTGIR-002 ENSP00000468970 ENST00000596260	A0A0B4J2A7 [Direct mapping] Prostacyclin receptor; Prostaglandin I2 (Prostacyclin) receptor (IP), isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	296 aa 31.8 kDa	No	6
PTGIR-004 ENSP00000470566 ENST00000597185	M0QZI2 [Direct mapping] Prostacyclin receptor Show all	Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	115 aa 12.2 kDa	No	0
PTGIR-005 ENSP00000470799 ENST00000598865	M0QZW0 [Direct mapping] Prostacyclin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	174 aa 18.8 kDa	No	2
PTGIR-006 ENSP00000469408 ENST00000594275	M0QXV5 [Direct mapping] Prostacyclin receptor Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	143 aa 15.2 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.