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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CALM3
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CALM3

Gene description

Calmodulin 3 (phosphorylase kinase, delta)

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
RAS pathway related proteins
Transporters

Predicted localization

Intracellular

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Approved based on 1 antibody.
HPA044999
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in lung cancer (unfavourable) and thyroid cancer (favourable).
Lung cancer p<0.001
Thyroid cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA044999

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues showed weak to moderate cytoplasmic and membranous immunoreactivity. Lymphomas and renal cancers along with several gliomas, ovarian, lung and liver cancers were negative.

GENE INFORMATION

Gene name

CALM3 (HGNC Symbol)

Synonyms

PHKD

Description

Calmodulin 3 (phosphorylase kinase, delta) (HGNC Symbol)

Entrez gene summary

Chromosome

19

Cytoband

q13.32

Chromosome location (bp)

46601074 - 46610793

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160014 (version 83.38)

Entrez gene

808

UniProt

P62158 (UniProt - Evidence at protein level)

neXtProt

NX_P62158

Antibodypedia

CALM3 antibodies

PROTEIN BROWSER

CALM3-001
CALM3-003
CALM3-007
CALM3-009
CALM3-013
CALM3-014
CALM3-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CALM3-001
ENSP00000291295
ENST00000291295
P62158 [Direct mapping]
Calmodulin
B4DJ51 [Target identity:100%; Query identity:100%]
Calmodulin 1 (Phosphorylase kinase, delta), isoform CRA_a; Calmodulin 3 (Phosphorylase kinase, delta), isoform CRA_b; Epididymis secretory protein Li 72; cDNA FLJ61744, highly similar to Calmodulin
Show all
Transporters
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000922 [spindle pole]
GO:0002027 [regulation of heart rate]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002576 [platelet degranulation]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005980 [glycogen catabolic process]
GO:0006006 [glucose metabolic process]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0021762 [substantia nigra development]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030017 [sarcomere]
GO:0030168 [platelet activation]
GO:0030801 [positive regulation of cyclic nucleotide metabolic process]
GO:0031432 [titin binding]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0031982 [vesicle]
GO:0031996 [thioesterase binding]
GO:0031997 [N-terminal myristoylation domain binding]
GO:0032465 [regulation of cytokinesis]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0034704 [calcium channel complex]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043274 [phospholipase binding]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0046209 [nitric oxide metabolic process]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051343 [positive regulation of cyclic-nucleotide phosphodiesterase activity]
GO:0051592 [response to calcium ion]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0072542 [protein phosphatase activator activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
Show all
149 aa
16.8 kDa
No 0
CALM3-003
ENSP00000472141
ENST00000596362
P62158 [Direct mapping]
Calmodulin
B4DJ51 [Target identity:100%; Query identity:100%]
Calmodulin 1 (Phosphorylase kinase, delta), isoform CRA_a; Calmodulin 3 (Phosphorylase kinase, delta), isoform CRA_b; Epididymis secretory protein Li 72; cDNA FLJ61744, highly similar to Calmodulin
Show all
Transporters
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000922 [spindle pole]
GO:0002027 [regulation of heart rate]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002576 [platelet degranulation]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005980 [glycogen catabolic process]
GO:0006006 [glucose metabolic process]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0021762 [substantia nigra development]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030017 [sarcomere]
GO:0030168 [platelet activation]
GO:0030801 [positive regulation of cyclic nucleotide metabolic process]
GO:0031432 [titin binding]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0031982 [vesicle]
GO:0031996 [thioesterase binding]
GO:0031997 [N-terminal myristoylation domain binding]
GO:0032465 [regulation of cytokinesis]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0034704 [calcium channel complex]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043274 [phospholipase binding]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0046209 [nitric oxide metabolic process]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051343 [positive regulation of cyclic-nucleotide phosphodiesterase activity]
GO:0051592 [response to calcium ion]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0072542 [protein phosphatase activator activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
Show all
149 aa
16.8 kDa
No 0
CALM3-007
ENSP00000471225
ENST00000599839
Q96HY3 [Direct mapping]
CALM1 protein; Calmodulin; Calmodulin 2 (Phosphorylase kinase, delta), isoform CRA_a; Calmodulin 3 (Phosphorylase kinase, delta), isoform CRA_a; LP7057 protein
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
Show all
113 aa
12.9 kDa
No 0
CALM3-009
ENSP00000375785
ENST00000391918
Q96HY3 [Direct mapping]
CALM1 protein; Calmodulin; Calmodulin 2 (Phosphorylase kinase, delta), isoform CRA_a; Calmodulin 3 (Phosphorylase kinase, delta), isoform CRA_a; LP7057 protein
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
Show all
113 aa
12.9 kDa
No 0
CALM3-013
ENSP00000470308
ENST00000597743
M0QZ52 [Direct mapping]
Calmodulin; Calmodulin 3 (Phosphorylase kinase, delta), isoform CRA_d
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005509 [calcium ion binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
Show all
83 aa
9.4 kDa
No 0
CALM3-014
ENSP00000470502
ENST00000598871
Q96HY3 [Direct mapping]
CALM1 protein; Calmodulin; Calmodulin 2 (Phosphorylase kinase, delta), isoform CRA_a; Calmodulin 3 (Phosphorylase kinase, delta), isoform CRA_a; LP7057 protein
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
Show all
113 aa
12.9 kDa
No 0
CALM3-015
ENSP00000468877
ENST00000594523
Q96HY3 [Direct mapping]
CALM1 protein; Calmodulin; Calmodulin 2 (Phosphorylase kinase, delta), isoform CRA_a; Calmodulin 3 (Phosphorylase kinase, delta), isoform CRA_a; LP7057 protein
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
Show all
113 aa
12.9 kDa
No 0

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