Expression of CCDC28B in cancer - Summary - The Human Protein Atlas

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CCDC28B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC28B
Gene description	Coiled-coil domain containing 28B
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA028589
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and breast cancer (favourable).
Pancreatic cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Urothelial cancer

STAINING SUMMARY

HPA028589

GENE INFORMATION
Gene name	CCDC28B (HGNC Symbol)
Synonyms	MGC1203, RP4-622L5.5
Description	Coiled-coil domain containing 28B (HGNC Symbol)
Entrez gene summary	The product of this gene localizes to centrosomes and basal bodies. The protein colocalizes with several proteins associated with Bardet-Biedl syndrome (BBS) and participates in the regulation of cilia development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	1
Cytoband	p35.2
Chromosome location (bp)	32200386 - 32205387
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160050 (version 83.38)
Entrez gene	79140
UniProt	Q9BUN5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BUN5
Antibodypedia	CCDC28B antibodies

PROTEIN BROWSER

CCDC28B-001	CCDC28B-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC28B-001 ENSP00000413017 ENST00000421922	Q9BUN5 [Direct mapping] Coiled-coil domain-containing protein 28B Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0042384 [cilium assembly] Show all	241 aa 26.9 kDa	No	0
CCDC28B-002 ENSP00000362704 ENST00000373602	Q9BUN5 [Direct mapping] Coiled-coil domain-containing protein 28B Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0042384 [cilium assembly] Show all	200 aa 22 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.