Expression of IQCC in cancer - Summary - The Human Protein Atlas

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IQCC

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IQCC
Gene description	IQ motif containing C
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a majority of tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA028602 , HPA028686
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), testis cancer (favourable) and lung cancer (favourable).
Pancreatic cancer p<0.001 Testis cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028602	HPA028686

GENE INFORMATION
Gene name	IQCC (HGNC Symbol)
Synonyms	FLJ10547
Description	IQ motif containing C (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p35.2
Chromosome location (bp)	32205661 - 32208687
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160051 (version 83.38)
Entrez gene	55721
UniProt	Q4KMZ1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q4KMZ1
Antibodypedia	IQCC antibodies

PROTEIN BROWSER

IQCC-001	IQCC-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IQCC-001 ENSP00000291358 ENST00000291358	Q4KMZ1 [Direct mapping] IQ domain-containing protein C Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	466 aa 53 kDa	No	0
IQCC-002 ENSP00000442291 ENST00000537469	Q4KMZ1 [Direct mapping] IQ domain-containing protein C Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	546 aa 62 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.