Expression of CCDC58 in cancer - Summary - The Human Protein Atlas

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CCDC58

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC58
Gene description	Coiled-coil domain containing 58
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA047777
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), endometrial cancer (unfavourable) and urothelial cancer (favourable).
Liver cancer p<0.001 Endometrial cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047777

GENE INFORMATION
Gene name	CCDC58 (HGNC Symbol)
Synonyms	FLJ33273
Description	Coiled-coil domain containing 58 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q21.1
Chromosome location (bp)	122359591 - 122383231
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160124 (version 83.38)
Entrez gene	131076
UniProt	Q4VC31 (UniProt - Evidence at protein level)
neXtProt	NX_Q4VC31
Antibodypedia	CCDC58 antibodies

PROTEIN BROWSER

CCDC58-001	CCDC58-002	CCDC58-003	CCDC58-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC58-001 ENSP00000291458 ENST00000291458	Q4VC31 [Direct mapping] Coiled-coil domain-containing protein 58 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	144 aa 16.6 kDa	No	0
CCDC58-002 ENSP00000420769 ENST00000497726	C9JBU9 [Direct mapping] Coiled-coil domain-containing protein 58 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		53 aa 6.3 kDa	No	0
CCDC58-003 ENSP00000420248 ENST00000479899	C9JQ41 [Direct mapping] Coiled-coil domain-containing protein 58 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 15.3 kDa	No	0
CCDC58-005 ENSP00000418810 ENST00000479414	H7C525 [Direct mapping] Coiled-coil domain-containing protein 58 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		141 aa 16.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.