Expression of TFF1 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TFF1
Gene description	Trefoil factor 1
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (breast cancer, colorectal cancer, pancreatic cancer, stomach cancer)
HPA (cell line):	Cell line enriched (MCF7)
HPA (normal tissue):	Tissue enriched (stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in the superficial layer of gastric mucosa and goblet cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA003425 , CAB002170
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable) and endometrial cancer (favourable).
Breast cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (breast cancer, colorectal cancer, pancreatic cancer, stomach cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA003425	CAB002170

GENE INFORMATION
Gene name	TFF1 (HGNC Symbol)
Synonyms	BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2
Description	Trefoil factor 1 (HGNC Symbol)
Entrez gene summary	Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	42362282 - 42366594
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160182 (version 83.38)
Entrez gene	7031
UniProt	P04155 (UniProt - Evidence at protein level)
neXtProt	NX_P04155
Antibodypedia	TFF1 antibodies

PROTEIN BROWSER

TFF1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TFF1-001 ENSP00000291527 ENST00000291527	P04155 [Direct mapping] Trefoil factor 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0007586 [digestion] GO:0008083 [growth factor activity] GO:0008285 [negative regulation of cell proliferation] GO:0010039 [response to iron ion] GO:0030154 [cell differentiation] GO:0030277 [maintenance of gastrointestinal epithelium] GO:0035902 [response to immobilization stress] GO:0043434 [response to peptide hormone] Show all	84 aa 9.1 kDa	Yes	0