Expression of SLC37A1 in cancer - Summary - The Human Protein Atlas

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SLC37A1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC37A1
Gene description	Solute carrier family 37 (glucose-6-phosphate transporter), member 1
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HEL)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA030418 , CAB034154
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable) and endometrial cancer (favourable).
Thyroid cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030418	CAB034154

GENE INFORMATION
Gene name	SLC37A1
Synonyms
Description	Solute carrier family 37 (glucose-6-phosphate transporter), member 1 (HGNC Symbol)
Entrez gene summary	SLC37A1, a member of the sugar-phosphate transport family, transports glycerol-3-phosphate (G3P) between cellular compartments for its utilization in several compartment-specific biochemical pathways.[supplied by OMIM, Jul 2004]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	42496008 - 42581440
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160190 (version 83.38)
Entrez gene	54020
UniProt	P57057 (UniProt - Evidence at transcript level)
neXtProt	NX_P57057
Antibodypedia	SLC37A1 antibodies

PROTEIN BROWSER

SLC37A1-001	SLC37A1-002	SLC37A1-004	SLC37A1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC37A1-001 ENSP00000381383 ENST00000398341	P57057 [Direct mapping] Glycerol-3-phosphate transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0006820 [anion transport] GO:0008643 [carbohydrate transport] GO:0015315 [organophosphate:inorganic phosphate antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035435 [phosphate ion transmembrane transport] GO:0055062 [phosphate ion homeostasis] GO:0055085 [transmembrane transport] Show all	533 aa 57.6 kDa	No	>9
SLC37A1-002 ENSP00000410129 ENST00000419522	A0A0C4DG69 [Direct mapping] Glycerol-3-phosphate transporter Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006820 [anion transport] GO:0015315 [organophosphate:inorganic phosphate antiporter activity] GO:0016021 [integral component of membrane] GO:0035435 [phosphate ion transmembrane transport] GO:0055062 [phosphate ion homeostasis] GO:0055085 [transmembrane transport] Show all	18 aa 2.1 kDa	No	0
SLC37A1-004 ENSP00000344648 ENST00000352133	P57057 [Direct mapping] Glycerol-3-phosphate transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0006820 [anion transport] GO:0008643 [carbohydrate transport] GO:0015315 [organophosphate:inorganic phosphate antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035435 [phosphate ion transmembrane transport] GO:0055062 [phosphate ion homeostasis] GO:0055085 [transmembrane transport] Show all	533 aa 57.6 kDa	No	>9
SLC37A1-005 ENSP00000381385 ENST00000398343	A0A0C4DG69 [Direct mapping] Glycerol-3-phosphate transporter Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006820 [anion transport] GO:0015315 [organophosphate:inorganic phosphate antiporter activity] GO:0016021 [integral component of membrane] GO:0035435 [phosphate ion transmembrane transport] GO:0055062 [phosphate ion homeostasis] GO:0055085 [transmembrane transport] Show all	18 aa 2.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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