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PDXK

GENERAL INFORMATION

Gene name

 PDXK

Gene description

 Pyridoxal (pyridoxine, vitamin B6) kinase

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 4 antibodies.
HPA030196 , HPA030197 , HPA030198 , CAB033918
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA030196
HPA030197
HPA030198
CAB033918

GENE INFORMATION

Gene name

 PDXK (HGNC Symbol)

Synonyms

 C21orf124, C21orf97, FLJ21324, FLJ31940, MGC15873, PKH, PNK, PRED79

Description

 Pyridoxal (pyridoxine, vitamin B6) kinase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 43719094 - 43762307

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160209 (version 83.38)

Entrez gene

 8566

UniProt

 O00764 (UniProt - Evidence at protein level)

neXtProt

 NX_O00764

Antibodypedia

 PDXK antibodies

PROTEIN BROWSER
PDXK-001
PDXK-002
PDXK-010
PDXK-018
PDXK-019
PDXK-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDXK-001
ENSP00000418359
ENST00000468090
O00764 [Direct mapping]
Pyridoxal kinase
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Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008478 [pyridoxal kinase activity]
GO:0009443 [pyridoxal 5'-phosphate salvage]
GO:0016310 [phosphorylation]
GO:0030170 [pyridoxal phosphate binding]
GO:0030955 [potassium ion binding]
GO:0031402 [sodium ion binding]
GO:0031403 [lithium ion binding]
GO:0042803 [protein homodimerization activity]
GO:0042816 [vitamin B6 metabolic process]
GO:0042823 [pyridoxal phosphate biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 284 aa
31.8 kDa 		No 0
PDXK-002
ENSP00000291565
ENST00000291565
O00764 [Direct mapping]
Pyridoxal kinase
V9HWC3 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 1a; HCG401289, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008478 [pyridoxal kinase activity]
GO:0009443 [pyridoxal 5'-phosphate salvage]
GO:0016310 [phosphorylation]
GO:0030170 [pyridoxal phosphate binding]
GO:0030955 [potassium ion binding]
GO:0031402 [sodium ion binding]
GO:0031403 [lithium ion binding]
GO:0042803 [protein homodimerization activity]
GO:0042816 [vitamin B6 metabolic process]
GO:0042823 [pyridoxal phosphate biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 312 aa
35.1 kDa 		No 0
PDXK-010
ENSP00000420708
ENST00000467908
F2Z2Y4 [Direct mapping]
Pyridoxal kinase
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   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008478 [pyridoxal kinase activity]
GO:0009443 [pyridoxal 5'-phosphate salvage]
GO:0016310 [phosphorylation]
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 272 aa
30.6 kDa 		No 0
PDXK-018
ENSP00000381155
ENST00000398081
A8MV33 [Direct mapping]
HCG401289, isoform CRA_b; Pyridoxal kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008478 [pyridoxal kinase activity]
GO:0009443 [pyridoxal 5'-phosphate salvage]
GO:0016310 [phosphorylation]
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 87 aa
9.6 kDa 		No 0
PDXK-019
ENSP00000333624
ENST00000327574
A8MT14 [Direct mapping]
HCG401289, isoform CRA_e; Pyridoxal kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 148 aa
16.9 kDa 		No 0
PDXK-201
ENSP00000479315
ENST00000621478
A0A0B4J2C9 [Direct mapping]
Pyridoxal kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 162 aa
17.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.