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G6PD

GENERAL INFORMATION

Gene name

 G6PD

Gene description

 Glucose-6-phosphate dehydrogenase

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues, highly abundant in immune cells and in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA000247 , HPA000834
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000247
HPA000834

GENE INFORMATION

Gene name

 G6PD (HGNC Symbol)

Synonyms

 G6PD1

Description

 Glucose-6-phosphate dehydrogenase (HGNC Symbol)

Entrez gene summary

 This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 154531391 - 154547572

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160211 (version 83.38)

Entrez gene

 2539

UniProt

 P11413 (UniProt - Evidence at protein level)

neXtProt

 NX_P11413

Antibodypedia

 G6PD antibodies

PROTEIN BROWSER
G6PD-001
G6PD-002
G6PD-005
G6PD-006
G6PD-007
G6PD-010
G6PD-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
G6PD-001
ENSP00000377192
ENST00000393562
P11413 [Direct mapping]
Glucose-6-phosphate 1-dehydrogenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345 [glucose-6-phosphate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005536 [glucose binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006739 [NADP metabolic process]
GO:0006740 [NADPH regeneration]
GO:0006749 [glutathione metabolic process]
GO:0009051 [pentose-phosphate shunt, oxidative branch]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010467 [gene expression]
GO:0010734 [negative regulation of protein glutathionylation]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0019322 [pentose biosynthetic process]
GO:0021762 [substantia nigra development]
GO:0030246 [carbohydrate binding]
GO:0032094 [response to food]
GO:0034599 [cellular response to oxidative stress]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043249 [erythrocyte maturation]
GO:0043523 [regulation of neuron apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0046390 [ribose phosphate biosynthetic process]
GO:0050661 [NADP binding]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 545 aa
62.5 kDa 		No 0
G6PD-002
ENSP00000395599
ENST00000439227
E7EUI8 [Direct mapping]
Glucose-6-phosphate 1-dehydrogenase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345 [glucose-6-phosphate dehydrogenase activity]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006006 [glucose metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
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 339 aa
38.5 kDa 		No 0
G6PD-005
ENSP00000394690
ENST00000433845
E9PD92 [Direct mapping]
Glucose-6-phosphate 1-dehydrogenase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345 [glucose-6-phosphate dehydrogenase activity]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006006 [glucose metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
Show all
 256 aa
29.5 kDa 		No 0
G6PD-006
ENSP00000377194
ENST00000393564
P11413 [Direct mapping]
Glucose-6-phosphate 1-dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345 [glucose-6-phosphate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005536 [glucose binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006739 [NADP metabolic process]
GO:0006740 [NADPH regeneration]
GO:0006749 [glutathione metabolic process]
GO:0009051 [pentose-phosphate shunt, oxidative branch]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010467 [gene expression]
GO:0010734 [negative regulation of protein glutathionylation]
GO:0016020 [membrane]
GO:0019322 [pentose biosynthetic process]
GO:0021762 [substantia nigra development]
GO:0034599 [cellular response to oxidative stress]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043249 [erythrocyte maturation]
GO:0044281 [small molecule metabolic process]
GO:0046390 [ribose phosphate biosynthetic process]
GO:0050661 [NADP binding]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 515 aa
59.3 kDa 		No 0
G6PD-007
ENSP00000400648
ENST00000440967
E7EM57 [Direct mapping]
Glucose-6-phosphate 1-dehydrogenase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345 [glucose-6-phosphate dehydrogenase activity]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006006 [glucose metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
Show all
 320 aa
36.5 kDa 		No 0
G6PD-010
ENSP00000358633
ENST00000369620
P11413 [Direct mapping]
Glucose-6-phosphate 1-dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345 [glucose-6-phosphate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005536 [glucose binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006739 [NADP metabolic process]
GO:0006740 [NADPH regeneration]
GO:0006749 [glutathione metabolic process]
GO:0009051 [pentose-phosphate shunt, oxidative branch]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010467 [gene expression]
GO:0010734 [negative regulation of protein glutathionylation]
GO:0016020 [membrane]
GO:0019322 [pentose biosynthetic process]
GO:0021762 [substantia nigra development]
GO:0034599 [cellular response to oxidative stress]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043249 [erythrocyte maturation]
GO:0044281 [small molecule metabolic process]
GO:0046390 [ribose phosphate biosynthetic process]
GO:0050661 [NADP binding]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 561 aa
63.8 kDa 		No 0
G6PD-201
ENSP00000483686
ENST00000621232
P11413 [Direct mapping]
Glucose-6-phosphate 1-dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345 [glucose-6-phosphate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005536 [glucose binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006739 [NADP metabolic process]
GO:0006740 [NADPH regeneration]
GO:0006749 [glutathione metabolic process]
GO:0009051 [pentose-phosphate shunt, oxidative branch]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010467 [gene expression]
GO:0010734 [negative regulation of protein glutathionylation]
GO:0016020 [membrane]
GO:0019322 [pentose biosynthetic process]
GO:0021762 [substantia nigra development]
GO:0034599 [cellular response to oxidative stress]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043249 [erythrocyte maturation]
GO:0044281 [small molecule metabolic process]
GO:0046390 [ribose phosphate biosynthetic process]
GO:0050661 [NADP binding]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 515 aa
59.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.