Expression of RRP1 in cancer - Summary - The Human Protein Atlas

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RRP1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RRP1
Gene description	Ribosomal RNA processing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nucleolar expression in several cell types with highest levels in neuronal cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA016818 , HPA018166
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016818	HPA018166

GENE INFORMATION
Gene name	RRP1 (HGNC Symbol)
Synonyms	D21S2056E, NNP-1, Nop52, RRP1A
Description	Ribosomal RNA processing 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	43789513 - 43805293
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160214 (version 83.38)
Entrez gene	8568
UniProt	P56182 (UniProt - Evidence at protein level)
neXtProt	NX_P56182
Antibodypedia	RRP1 antibodies

PROTEIN BROWSER

RRP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RRP1-001 ENSP00000417464 ENST00000497547	P56182 [Direct mapping] Ribosomal RNA processing protein 1 homolog A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0030688 [preribosome, small subunit precursor] GO:0044822 [poly(A) RNA binding] Show all	461 aa 52.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.