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No internal RNA expression data available for correlation. External characterization data supports antibody staining but no internal RNA data available for correlation.
Most malignant cells showed moderate cytoplasmic positivity. Most pancreatic cancer and several renal cancers were strongly stained. A majority of malignant gliomas, lymphomas and melanomas as well as seminomas, urothelial, skin and cervical cancer were weakly stained or negative.
GENE INFORMATION
Gene name
AIRE (HGNC Symbol)
Synonyms
APECED, APS1, PGA1
Description
Autoimmune regulator (HGNC Symbol)
Entrez gene summary
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]