Expression of ITGB2 in cancer - Summary

GENERAL INFORMATION
Gene name	ITGB2
Gene description	Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Protein class	CD markers Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	16
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (THP-1, U-937)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic and membranous expression in immune cells, mainly in lymphoid tissue and bone marrow.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA008877 , HPA016894
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA008877	HPA016894

GENE INFORMATION
Gene name	ITGB2 (HGNC Symbol)
Synonyms	CD18, LFA-1, MAC-1, MFI7
Description	Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (HGNC Symbol)
Entrez gene summary	This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	44885953 - 44931989
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160255 (version 83.38)
Entrez gene	3689
UniProt	P05107 (UniProt - Evidence at protein level)
neXtProt	NX_P05107
Antibodypedia	ITGB2 antibodies

PROTEIN BROWSER

ITGB2-001	ITGB2-002	ITGB2-003	ITGB2-004	ITGB2-005	ITGB2-008	ITGB2-010	ITGB2-014	ITGB2-015	ITGB2-016	ITGB2-017	ITGB2-021	ITGB2-022	ITGB2-024	ITGB2-201	ITGB2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITGB2-001 ENSP00000347279 ENST00000355153	P05107 [Direct mapping] Integrin beta-2 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001948 [glycoprotein binding] GO:0002224 [toll-like receptor signaling pathway] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007159 [leukocyte cell-cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0008305 [integrin complex] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0030198 [extracellular matrix organization] GO:0030369 [ICAM-3 receptor activity] GO:0030593 [neutrophil chemotaxis] GO:0034113 [heterotypic cell-cell adhesion] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034687 [integrin alphaL-beta2 complex] GO:0035987 [endodermal cell differentiation] GO:0043113 [receptor clustering] GO:0043235 [receptor complex] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	769 aa 84.8 kDa	Yes	1
ITGB2-002 ENSP00000380948 ENST00000397850	P05107 [Direct mapping] Integrin beta-2 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001948 [glycoprotein binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002523 [leukocyte migration involved in inflammatory response] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007159 [leukocyte cell-cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007267 [cell-cell signaling] GO:0007568 [aging] GO:0007596 [blood coagulation] GO:0008305 [integrin complex] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0019901 [protein kinase binding] GO:0030101 [natural killer cell activation] GO:0030198 [extracellular matrix organization] GO:0030369 [ICAM-3 receptor activity] GO:0030593 [neutrophil chemotaxis] GO:0032403 [protein complex binding] GO:0034113 [heterotypic cell-cell adhesion] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034687 [integrin alphaL-beta2 complex] GO:0035987 [endodermal cell differentiation] GO:0043113 [receptor clustering] GO:0043235 [receptor complex] GO:0043542 [endothelial cell migration] GO:0045087 [innate immune response] GO:0045123 [cellular extravasation] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0050900 [leukocyte migration] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	769 aa 84.8 kDa	Yes	1
ITGB2-003 ENSP00000380952 ENST00000397854	D3DSM0 [Direct mapping] Integrin beta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008305 [integrin complex] Show all	712 aa 78.4 kDa	Yes	1
ITGB2-004 ENSP00000380955 ENST00000397857	P05107 [Direct mapping] Integrin beta-2 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001948 [glycoprotein binding] GO:0002224 [toll-like receptor signaling pathway] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007159 [leukocyte cell-cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0008305 [integrin complex] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0030198 [extracellular matrix organization] GO:0030369 [ICAM-3 receptor activity] GO:0030593 [neutrophil chemotaxis] GO:0034113 [heterotypic cell-cell adhesion] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034687 [integrin alphaL-beta2 complex] GO:0035987 [endodermal cell differentiation] GO:0043113 [receptor clustering] GO:0043235 [receptor complex] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	769 aa 84.8 kDa	Yes	1
ITGB2-005 ENSP00000380950 ENST00000397852	P05107 [Direct mapping] Integrin beta-2 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001948 [glycoprotein binding] GO:0002224 [toll-like receptor signaling pathway] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007159 [leukocyte cell-cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0008305 [integrin complex] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0030198 [extracellular matrix organization] GO:0030369 [ICAM-3 receptor activity] GO:0030593 [neutrophil chemotaxis] GO:0034113 [heterotypic cell-cell adhesion] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034687 [integrin alphaL-beta2 complex] GO:0035987 [endodermal cell differentiation] GO:0043113 [receptor clustering] GO:0043235 [receptor complex] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	769 aa 84.8 kDa	Yes	1
ITGB2-008 ENSP00000380944 ENST00000397846	A8MVG7 [Direct mapping] Integrin beta-2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008305 [integrin complex] Show all	108 aa 11.4 kDa	Yes	0
ITGB2-010 ENSP00000317697 ENST00000320216	J3KNI6 [Direct mapping] Integrin beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008305 [integrin complex] Show all	322 aa 35.7 kDa	No	0
ITGB2-014 ENSP00000429683 ENST00000521995	E5RHT0 [Direct mapping] Integrin beta-2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008305 [integrin complex] Show all	49 aa 5.3 kDa	Yes	0
ITGB2-015 ENSP00000428413 ENST00000517563	E5RIG7 [Direct mapping] Integrin beta Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008305 [integrin complex] Show all	120 aa 13 kDa	Yes	0
ITGB2-016 ENSP00000428870 ENST00000517819	E5RFI0 [Direct mapping] Integrin beta Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008305 [integrin complex] Show all	70 aa 7.6 kDa	Yes	0
ITGB2-017 ENSP00000428125 ENST00000522688	E5RK54 [Direct mapping] Integrin beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008305 [integrin complex] Show all	49 aa 5.3 kDa	No	0
ITGB2-021 ENSP00000430901 ENST00000524251	E5RHE6 [Direct mapping] Integrin beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 4 kDa	No	0
ITGB2-022 ENSP00000428979 ENST00000522931	E5RK25 [Direct mapping] Integrin beta Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008305 [integrin complex] Show all	160 aa 17.6 kDa	Yes	0
ITGB2-024 ENSP00000428503 ENST00000523663	E7EVZ9 [Direct mapping] Integrin beta Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008305 [integrin complex] Show all	166 aa 18.3 kDa	Yes	0
ITGB2-201 ENSP00000303242 ENST00000302347	P05107 [Direct mapping] Integrin beta-2 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001948 [glycoprotein binding] GO:0002224 [toll-like receptor signaling pathway] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007159 [leukocyte cell-cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0008305 [integrin complex] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0030198 [extracellular matrix organization] GO:0030369 [ICAM-3 receptor activity] GO:0030593 [neutrophil chemotaxis] GO:0034113 [heterotypic cell-cell adhesion] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034687 [integrin alphaL-beta2 complex] GO:0035987 [endodermal cell differentiation] GO:0043113 [receptor clustering] GO:0043235 [receptor complex] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	769 aa 84.8 kDa	Yes	1
ITGB2-202 ENSP00000480700 ENST00000610622	A0A087WX36 [Direct mapping] Integrin beta Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008305 [integrin complex] Show all	378 aa 41.7 kDa	Yes	0