Expression of RALGDS in cancer - Summary - The Human Protein Atlas

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RALGDS

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RALGDS
Gene description	Ral guanine nucleotide dissociation stimulator
Protein class	Cancer-related genes Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA025961 , CAB032582
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA025961	CAB032582

GENE INFORMATION
Gene name	RALGDS (HGNC Symbol)
Synonyms	RalGEF, RGDS, RGF
Description	Ral guanine nucleotide dissociation stimulator (HGNC Symbol)
Entrez gene summary	Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]
Chromosome	9
Cytoband
Chromosome location (bp)	133097720 - 133149334
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160271 (version 83.38)
Entrez gene	5900
UniProt	Q12967 (UniProt - Evidence at protein level)
neXtProt	NX_Q12967
Antibodypedia	RALGDS antibodies

PROTEIN BROWSER

RALGDS-001	RALGDS-002	RALGDS-003	RALGDS-010	RALGDS-201	RALGDS-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RALGDS-001 ENSP00000361120 ENST00000372050	Q12967 [Direct mapping] Ral guanine nucleotide dissociation stimulator Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005903 [brush border] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0030695 [GTPase regulator activity] GO:0043547 [positive regulation of GTPase activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050790 [regulation of catalytic activity] Show all	914 aa 100.6 kDa	No	0
RALGDS-002 ENSP00000361117 ENST00000372047	Q12967 [Direct mapping] Ral guanine nucleotide dissociation stimulator Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005903 [brush border] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0030695 [GTPase regulator activity] GO:0043547 [positive regulation of GTPase activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050790 [regulation of catalytic activity] Show all	902 aa 99.3 kDa	No	0
RALGDS-003 ENSP00000376867 ENST00000393160	Q12967 [Direct mapping] Ral guanine nucleotide dissociation stimulator Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005903 [brush border] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0030695 [GTPase regulator activity] GO:0043547 [positive regulation of GTPase activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050790 [regulation of catalytic activity] Show all	859 aa 94.7 kDa	No	0
RALGDS-010 ENSP00000391814 ENST00000424572	Q5T7U6 [Direct mapping] Ral guanine nucleotide dissociation stimulator Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	309 aa 34.7 kDa	No	0
RALGDS-201 ENSP00000361132 ENST00000372062	Q12967 [Direct mapping] Ral guanine nucleotide dissociation stimulator Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005903 [brush border] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0030695 [GTPase regulator activity] GO:0043547 [positive regulation of GTPase activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050790 [regulation of catalytic activity] Show all	885 aa 97.3 kDa	No	0
RALGDS-202 ENSP00000376864 ENST00000393157	Q12967 [Direct mapping] Ral guanine nucleotide dissociation stimulator Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005903 [brush border] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0030695 [GTPase regulator activity] GO:0043547 [positive regulation of GTPase activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050790 [regulation of catalytic activity] Show all	913 aa 100.3 kDa	No	0

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