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Most tumour cells showed moderate cytoplasmic staining. Several lymphomas and prostate cancers as well as cases of ductal breast carcinomas, hepatocellular, colorectal and ovarian cancers displayed strong positivity. A majority of gliomas, gastric, renal, testicular and skin cancers were weakly stained or negative.
Most of the tumour tissues showed moderate to strong cytoplasmic positivity. Many lymphomas, gliomas, melanomas, lung and testis cancers were in general weakly stained or negative.
The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]