Expression of LSS in cancer - Summary - The Human Protein Atlas

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LSS

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LSS
Gene description	Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA032060 , HPA032062 , CAB034116
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable) and stomach cancer (unfavourable).
Urothelial cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA032060	HPA032062	CAB034116

GENE INFORMATION
Gene name	LSS (HGNC Symbol)
Synonyms	OSC
Description	Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	46188141 - 46228824
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160285 (version 83.38)
Entrez gene	4047
UniProt	P48449 (UniProt - Evidence at protein level)
neXtProt	NX_P48449
Antibodypedia	LSS antibodies

PROTEIN BROWSER

LSS-001	LSS-002	LSS-005	LSS-008	LSS-010	LSS-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LSS-001 ENSP00000380837 ENST00000397728	P48449 [Direct mapping] Lanosterol synthase Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000250 [lanosterol synthase activity] GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0006695 [cholesterol biosynthetic process] GO:0008202 [steroid metabolic process] GO:0016020 [membrane] GO:0016866 [intramolecular transferase activity] GO:0044281 [small molecule metabolic process] Show all	732 aa 83.3 kDa	No	0
LSS-002 ENSP00000348762 ENST00000356396	P48449 [Direct mapping] Lanosterol synthase Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000250 [lanosterol synthase activity] GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0006695 [cholesterol biosynthetic process] GO:0008202 [steroid metabolic process] GO:0016020 [membrane] GO:0016866 [intramolecular transferase activity] GO:0044281 [small molecule metabolic process] Show all	732 aa 83.3 kDa	No	0
LSS-005 ENSP00000391368 ENST00000450351	C9J315 [Direct mapping] Lanosterol synthase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] Show all	262 aa 29.6 kDa	No	0
LSS-008 ENSP00000410678 ENST00000419093	H7C3A5 [Direct mapping] Lanosterol synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 15.3 kDa	No	0
LSS-010 ENSP00000429133 ENST00000522411	P48449 [Direct mapping] Lanosterol synthase Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000250 [lanosterol synthase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0006695 [cholesterol biosynthetic process] GO:0008202 [steroid metabolic process] GO:0016020 [membrane] GO:0016866 [intramolecular transferase activity] GO:0044281 [small molecule metabolic process] Show all	721 aa 82.2 kDa	No	0
LSS-201 ENSP00000409191 ENST00000457828	P48449 [Direct mapping] Lanosterol synthase Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000250 [lanosterol synthase activity] GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0006695 [cholesterol biosynthetic process] GO:0008202 [steroid metabolic process] GO:0016020 [membrane] GO:0016866 [intramolecular transferase activity] GO:0044281 [small molecule metabolic process] Show all	652 aa 74.2 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.