Expression of CLDND2 in cancer - Summary - The Human Protein Atlas

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CLDND2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLDND2
Gene description	Claudin domain containing 2
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA056971
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056971

GENE INFORMATION
Gene name	CLDND2 (HGNC Symbol)
Synonyms	MGC33839
Description	Claudin domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.41
Chromosome location (bp)	51367098 - 51369003
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000160318 (version 83.38)
Entrez gene	125875
UniProt	Q8NHS1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NHS1
Antibodypedia	CLDND2 antibodies

PROTEIN BROWSER

CLDND2-001	CLDND2-002	CLDND2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLDND2-001 ENSP00000291715 ENST00000291715	Q8NHS1 [Direct mapping] Claudin domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	167 aa 18 kDa	No	3
CLDND2-002 ENSP00000472077 ENST00000601435	Q8NHS1 [Direct mapping] Claudin domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	167 aa 18 kDa	No	3
CLDND2-003 ENSP00000471912 ENST00000593841	M0R1J6 [Direct mapping] Claudin domain-containing protein 2 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	109 aa 11 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.